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CC BY-NC-ND 4.0 · Journal of Gastrointestinal Infections 2022; 12(01): 018-028
DOI: 10.1055/s-0042-1757541
Review Article

Systematic Review and Meta-Analysis: Seroprevalence, Vaccination Rates, and Response for Hepatitis A in Inflammatory Bowel Disease

Anuraag Jena 
1   Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Anupam Kumar Singh 
1   Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Pardhu B. Neelam 
1   Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Ritin Mohindra
2   Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Praveen Kumar-M
3   Nference Lab, India
,
Shubhra Mishra 
4   Department of Gastroenterology, Asian Institute of Gastroenterology, Chandigarh, India
,
Amol Patil
5   Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Vikas Suri
2   Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
,
Vishal Sharma 
1   Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
› Institutsangaben Funding None.
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Abstract

Introduction Guidelines recommend hepatitis A virus (HAV) vaccination in individuals with inflammatory bowel disease (IBD). We performed a systematic review to inform the clinical practice regarding this guidance.

Methods After a PubMed and Embase search, duplicates were removed and the remaining titles screened for studies reporting relevant outcomes. Pooled seroprevalence rates for HAV, pooled vaccination rates, and pooled seroconversion rates were calculated. We also calculated pooled relative risk of seroprevalence for HAV among IBD and control population. Heterogeneity was investigated using subgroup analysis.

Results The pooled seroprevalence of HAV antibodies in patients with IBD (14 studies, 2,370 patients) was 0.36 (95% confidence interval [CI]: 0.22–0.53, I 2 = 95%). On comparing the seroprevalence of HAV in IBD with controls (4 studies), the pooled relative risk was not different between the two (0.94, 95% CI: 0.66–1.34, I 2 = 76%). The pooled seroconversion rate after two doses of HAV vaccination (5 studies, 221 patients) was 0.93 (95% CI: 0.88–0.96, I 2 = 0%). Three studies (104 patients) reported on the seroconversion after a single dose of HAV vaccination and the pooled seroconversion rate was 0.47 (95% CI: 0.35–0.59, I 2 = 20%). The pooled vaccination rate for hepatitis A among patients with IBD (18 studies, 9,521 patients) was 0.21 (95% CI: 0.14–0.30, I 2 = 99%).

Conclusion Hepatitis A vaccine has good immunogenicity in patients with IBD. The decision to routinely vaccinate IBD patients may be made in light of underlying seroprevalence of HAV.

Keywords

hepatitis A - ulcerative colitis - Crohn's disease - inflammatory bowel disease - immunization - vaccine

Ethical Statement

Not applicable as there was no direct research on human or animals as the study is a systematic review of previously published literature.


Author Contributions

A.J.: Search, screening, RoB, draft, initial draft and approval. A.K.S.: RoB, approval. P.B.N., R.M., S.M.: Screening, approval. V.Suri, A.P., P.K.M.: Important intellectual content and approval. V.Sharma.: Conception, search, analysis, draft and revision.


Data Availability Statement

There is no data associated with this work and the data used are available in public domain.


Supplementary Material



Publikationsverlauf

Eingereicht: 08. Februar 2022

Angenommen: 25. Mai 2022

Artikel online veröffentlicht:
22. September 2023

© 2022. Gastroinstestinal Infection Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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