Download PDF
CC BY 4.0 · Eur J Dent 2023; 17(04): 974-999
DOI: 10.1055/s-0042-1757582
Review Article

Impact of Dentine Pretreatment with Matrix Metalloproteinase Inhibitors on Bond Strength of Coronal Composite Restorations: A Systematic Review and Meta-analysis of In Vitro Studies

Hasan Jamal
1   Paediatric Dentistry Department, Eastman Dental Institute, University College London, London, United Kingdom
2   Department of Biomaterials and Tissue Engineering, Royal Free Hospital, UCL Eastman Dental Institute, London, United Kingdom
,
Rayan Yaghmoor
2   Department of Biomaterials and Tissue Engineering, Royal Free Hospital, UCL Eastman Dental Institute, London, United Kingdom
3   Department of Microbial Diseases, UCL Eastman Dental Institute, Royal Free Hospital, London, United Kingdom
4   Department of Restorative Dentistry, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Hassan Abed
5   Department of Basic and Clinical Oral Sciences, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
,
Anne Young
2   Department of Biomaterials and Tissue Engineering, Royal Free Hospital, UCL Eastman Dental Institute, London, United Kingdom
,
Paul Ashley
1   Paediatric Dentistry Department, Eastman Dental Institute, University College London, London, United Kingdom
› Author Affiliations Funding The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (22UQU4350291DSR06).
› Further Information
Also available at
   Permissions and Reprints

Abstract

Matrix metalloproteinase (MMP) enzymes participate in collagen matrix degradation, including in dentine, potentially compromising bond strength. Therefore, MMP inhibitors have been hypothesized to improve restoration bond strength and stability. This systematic review aimed to evaluate the influence of different MMP inhibitors applied as dentine surface pretreatments on the immediate (24 hours) and longer term (months) bond strength of direct coronal composite restorations. This systematic literature review followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statement. A systematic literature search of three databases (Ovid MEDLINE, Ovid Embase, and Google Scholar) was conducted independently by two reviewers from inception to April 2022. An adapted quality assessment tool was independently applied by two reviewers for risk of bias assessment. RevMan v5.4 software was used for meta-analyses. A randomeffectsmodel was used to generatemean differences with 95% confidence intervals for treatment and control comparisons. The Q-test and I2-test were used to test for heterogeneity. The proportion of total variance across studies attributable to heterogeneity rather than chance was calculated. Overall effects were tested using the Z-test, while subgroup differences were tested using Chi-squared tests. Of 934 studies, 64 studies were included in the systematic review and 42 in the meta-analysis. Thirty-one MMP inhibitors were reported, three of which were included in the meta-analysis: 2% chlorhexidine (CHX), 0.3M carbodiimide (EDC), and 0.1% riboflavin (RIBO). Pretreatment with 2% CHX for 30 and 60 seconds did not significantly improve bond strength compared with controls either immediately or after long-termageing. However, pretreatment with 0.3MEDC and 0.1% RIBO (but not CHX) significantly improved bond strength compared with control groups both immediately and over time. Most studies showed a medium risk of bias. These in vitro findings pave the way for rationale clinical trialing of dentine surface pretreatment with MMP inhibitors to improve clinical outcomes.

Keywords

restorations - bond strength - matrix metalloproteinase inhibitors - enzymes - caries - dentine.


Publication History

Article published online:
18 November 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Buonocore MG. A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. J Dent Res 1955; 34 (06) 849-853
    CrossrefPubMedSearch in Google Scholar
  • 2 Van Meerbeek B, Yoshihara K, Van Landuyt K, Yoshida Y, Peumans M. From Buonocore's pioneering acid-etch technique to self-adhering restoratives. a status perspective of rapidly advancing dental adhesive technology. J Adhes Dent 2020; 22 (01) 7-34
    PubMedSearch in Google Scholar
  • 3 De Munck J, Van Landuyt K, Peumans M. et al. A critical review of the durability of adhesion to tooth tissue: methods and results. J Dent Res 2005; 84 (02) 118-132
    CrossrefPubMedSearch in Google Scholar
  • 4 Mjör IA, Moorhead JE, Dahl JE. Reasons for replacement of restorations in permanent teeth in general dental practice. Int Dent J 2000; 50 (06) 361-366
    CrossrefPubMedSearch in Google Scholar
  • 5 Breschi L, Maravic T, Cunha SR. et al. Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications. Dent Mater 2018; 34 (01) 78-96
    CrossrefPubMedSearch in Google Scholar
  • 6 Nakabayashi N, Nakamura M, Yasuda N. Hybrid layer as a dentin-bonding mechanism. J Esthet Dent 1991; 3 (04) 133-138
    CrossrefPubMedSearch in Google Scholar
  • 7 Frassetto A, Breschi L, Turco G. et al. Mechanisms of degradation of the hybrid layer in adhesive dentistry and therapeutic agents to improve bond durability–A literature review. Dent Mater 2016; 32 (02) e41-e53
    CrossrefPubMedSearch in Google Scholar
  • 8 Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003; 92 (08) 827-839
    CrossrefPubMedSearch in Google Scholar
  • 9 Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006; 69 (03) 562-573
    CrossrefPubMedSearch in Google Scholar
  • 10 Sulkala M, Tervahartiala T, Sorsa T, Larmas M, Salo T, Tjäderhane L. Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin. Arch Oral Biol 2007; 52 (02) 121-127
    CrossrefPubMedSearch in Google Scholar
  • 11 Mazzoni A, Mannello F, Tay FR. et al. Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin. J Dent Res 2007; 86 (05) 436-440
    CrossrefPubMedSearch in Google Scholar
  • 12 Tjäderhane L, Palosaari H, Wahlgren J, Larmas M, Sorsa T, Salo T. Human odontoblast culture method: the expression of collagen and matrix metalloproteinases (MMPs). Adv Dent Res 2001; 15 (01) 55-58
    CrossrefPubMedSearch in Google Scholar
  • 13 Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S. The role of matrix metalloproteinases (MMPs) in human caries. J Dent Res 2006; 85 (01) 22-32
    CrossrefPubMedSearch in Google Scholar
  • 14 Apolonio FM, Mazzoni A, Angeloni V. et al. Effect of a one-step self-etch adhesive on endogenous dentin matrix metalloproteinases. Eur J Oral Sci 2017; 125 (02) 168-172
    CrossrefPubMedSearch in Google Scholar
  • 15 DeVito-Moraes AG, Francci C, Vidal CM. et al. Phosphoric acid concentration affects dentinal MMPs activity. J Dent 2016; 53: 30-37
    CrossrefPubMedSearch in Google Scholar
  • 16 Pashley DH, Tay FR, Yiu C. et al. Collagen degradation by host-derived enzymes during aging. J Dent Res 2004; 83 (03) 216-221
    CrossrefPubMedSearch in Google Scholar
  • 17 Sabatini C, Pashley DH. Aging of adhesive interfaces treated with benzalkonium chloride and benzalkonium methacrylate. Eur J Oral Sci 2015; 123 (02) 102-107
    CrossrefPubMedSearch in Google Scholar
  • 18 Sabatini C, Patel SK. Matrix metalloproteinase inhibitory properties of benzalkonium chloride stabilizes adhesive interfaces. Eur J Oral Sci 2013; 121 (06) 610-616
    CrossrefPubMedSearch in Google Scholar
  • 19 Breschi L, Mazzoni A, Nato F. et al. Chlorhexidine stabilizes the adhesive interface: a 2-year in vitro study. Dent Mater 2010; 26 (04) 320-325
    CrossrefPubMedSearch in Google Scholar
  • 20 Kim J, Uchiyama T, Carrilho M. et al. Chlorhexidine binding to mineralized versus demineralized dentin powder. Dent Mater 2010; 26 (08) 771-778
    CrossrefPubMedSearch in Google Scholar
  • 21 Lenzi TL, Tedesco TK, Soares FZM, Loguercio AD, Rocha RdeO. Chlorhexidine does not increase immediate bond strength of etch-and-rinse adhesive to caries-affected dentin of primary and permanent teeth. Braz Dent J 2012; 23 (04) 438-442
    CrossrefPubMedSearch in Google Scholar
  • 22 Breschi L, Martin P, Mazzoni A. et al. Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer. Dent Mater 2010; 26 (06) 571-578
    CrossrefPubMedSearch in Google Scholar
  • 23 Barbosa CS, Kato MT, Buzalaf MA. Effect of supplementation of soft drinks with green tea extract on their erosive potential against dentine. Aust Dent J 2011; 56 (03) 317-321
    CrossrefPubMedSearch in Google Scholar
  • 24 Czech R, Oliveira C, França F, Basting R, Turssi C, Amaral F. Incorporation of EGCG into an etch-and-rinse adhesive system: mechanical properties and bond strength to caries affected dentin. J Adhes Sci Technol 2019; 33 (22) 2430-2442
    CrossrefSearch in Google Scholar
  • 25 Henn S, de Carvalho RV, Ogliari FA. et al. Addition of zinc methacrylate in dental polymers: MMP-2 inhibition and ultimate tensile strength evaluation. Clin Oral Investig 2012; 16 (02) 531-536
    CrossrefPubMedSearch in Google Scholar
  • 26 Page MJ, Shamseer L, Altman DG. et al. Epidemiology and reporting characteristics of systematic reviews of biomedical research: a cross-sectional study. PLoS Med 2016; 13 (05) e1002028
    CrossrefPubMedSearch in Google Scholar
  • 27 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372: n71
    CrossrefPubMedSearch in Google Scholar
  • 28 Montagner AF, Sarkis-Onofre R, Pereira-Cenci T, Cenci MS. MMP Inhibitors on Dentin Stability: A Systematic Review and Meta-analysis. J Dent Res 2014; 93 (08) 733-743
    CrossrefPubMedSearch in Google Scholar
  • 29 Green S, Higgins JP. Cochrane handbook for systematic reviews of interventions. Cochrane Collaboration. 2011 . Accessed September 7, 2022 at: https://handbook-5-1.cochrane.org/
    PubMedSearch in Google Scholar
  • 30 Baena E, Cunha SR, Maravić T. et al. Effect of chitosan as a cross-linker on matrix metalloproteinase activity and bond stability with different adhesive systems. Mar Drugs 2020; 18 (05) 263
    CrossrefPubMedSearch in Google Scholar
  • 31 Balloni ECP, Amaral FLBd, França FMG, Turssi CP, Basting RT. Influence of chlorhexidine in cavities prepared with ultrasonic or diamond tips on microtensile bond strength. J Adhes Sci Technol 2017; 31 (10) 1133-1141
    CrossrefSearch in Google Scholar
  • 32 Bravo C, Sampaio C, Hirata R, Puppin-Rontani RM, Mayoral JR, Giner L. In-vitro comparative study of the use of 2% chlorhexidine on microtensile bond strength of different dentin adhesives: a 6 months evaluation. Int J Morphol 2017; 35 (03) 893-900
    CrossrefSearch in Google Scholar
  • 33 de Faria Teixeira M, Basting RT, Turssi CP, França FMG, Amaral FLB. Effect of 2% chlorhexidine digluconate application and water storage on the bond strength to superficial and deep dentin. J Adhes Sci Technol 2015; 29 (12) 1258-1267
    CrossrefSearch in Google Scholar
  • 34 Comba A, Maravić T, Villalta V. et al. Effect of an ethanol cross-linker on universal adhesive. Dent Mater 2020; 36 (12) 1645-1654
    CrossrefPubMedSearch in Google Scholar
  • 35 Dávila-Sánchez A, Gutierrez MF, Bermudez JP. et al. Influence of flavonoids on long-term bonding stability on caries-affected dentin. Dent Mater 2020; 36 (09) 1151-1160
    CrossrefPubMedSearch in Google Scholar
  • 36 Costa CAG, Passos VF, Neri JR, Mendonça JS, Santiago SL. Effect of metalloproteinase inhibitors on bond strength of a self-etching adhesive on erosively demineralized dentin. J Adhes Dent 2019; 21 (04) 337-344
    PubMedSearch in Google Scholar
  • 37 El Baz MA, Aboulenien K. The effect of green tea extract as a matrix metalloproteinase inhibitor on the bond strength of resin composite. Egypt Dent J 2018; 64: 2807-2817
    CrossrefSearch in Google Scholar
  • 38 Fang H, Li QL, Han M, Mei ML, Chu CH. Anti-proteolytic property and bonding durability of mussel adhesive protein-modified dentin adhesive interface. Dent Mater 2017; 33 (10) 1075-1083
    CrossrefPubMedSearch in Google Scholar
  • 39 Fernandes FP, Adorno CC, da Silva TM. et al. Addition of EGCG to self-etching primer: effect on adhesive properties and bond stability to dentin. J Adhes Sci Technol 2021; 35: 1895-1908
    CrossrefSearch in Google Scholar
  • 40 Fialho MPN, Hass V, Nogueira RP. et al. Effect of epigallocatechin-3- gallate solutions on bond durability at the adhesive interface in caries-affected dentin. J Mech Behav Biomed Mater 2019; 91: 398-405
    CrossrefPubMedSearch in Google Scholar
  • 41 Gerhardt K, Oliveira C, França F, Basting R, Turssi C, Amaral F. Effect of epigallocatechin gallate, green tea extract and chlorhexidine application on long-term bond strength of self-etch adhesive to dentin. Int J Adhes Adhes 2016; 71: 23-27
    CrossrefSearch in Google Scholar
  • 42 Campos R, Oliveira C, Macedo J. et al. Effect of zinc chloride added to self-etching primer on bond strength to caries-affected dentin and chemical-physical-mechanical properties of adhesives. Int J Adhes Adhes 2019; 95: 102412
    CrossrefSearch in Google Scholar
  • 43 Giacomini MC, Scaffa PMC, Gonçalves RS. et al. Profile of a 10-MDP-based universal adhesive system associated with chlorhexidine: dentin bond strength and in situ zymography performance. J Mech Behav Biomed Mater 2020; 110: 103925
    CrossrefPubMedSearch in Google Scholar
  • 44 Grandizoli DRP, Pinheiro SL. Influence of protease inhibitors on bond degradation of self-etch adhesive systems to caries-affected dentin: an in vitro study. Adv Biol Chem 2018; 8: 15-28
    CrossrefSearch in Google Scholar
  • 45 Karrabi M, Danesh Kazemi A. Comparison of chlorhexidine 2 and sodium hypochlorite 5 as rewetting agents on resin-dentin micro tensile bond strength. J Dent Mater Tech 2016; 5 (04) 189-195
    Search in Google Scholar
  • 46 Kasraei S, Malek M, Khamverdi Z, Mojtahedi M. The efficacy of riboflavin for collagen cross-linking and optimizing the bond strength of an etch and rinse adhesive system to dentin. Avicenna J Dent Res 2017; 9: e13254
    CrossrefSearch in Google Scholar
  • 47 Lenzi TL, Tedesco TK, Soares FZM, Loguercio AD, de Oliveira Rocha R. Chlorhexidine application for bond strength preservation in artificially-created caries-affected primary dentin. Int J Adhes Adhes 2014; 54: 51-56
    CrossrefSearch in Google Scholar
  • 48 Li J, Chen B, Hong N, Wu S, Li Y. Effect of baicalein on matrix metalloproteinases and durability of resin-dentin bonding. Oper Dent 2018; 43 (04) 426-436
    CrossrefPubMedSearch in Google Scholar
  • 49 Loguercio AD, Hass V, Gutierrez MF. et al. Five-year effects of chlorhexidine on the in vitro durability of resin/dentin interfaces. J Adhes Dent 2016; 18 (01) 35-42
    PubMedSearch in Google Scholar
  • 50 Loguercio AD, Stanislawczuk R, Polli LG, Costa JA, Michel MD, Reis A. Influence of chlorhexidine digluconate concentration and application time on resin-dentin bond strength durability. Eur J Oral Sci 2009; 117 (05) 587-596
    CrossrefPubMedSearch in Google Scholar
  • 51 Maravic T, Breschi L, Comba A. et al. Experimental use of an acrolein-based primer as collagen cross-linker for dentine bonding. J Dent 2018; 68: 85-90
    CrossrefPubMedSearch in Google Scholar
  • 52 Mazzoni A, Angeloni V, Apolonio FM. et al. Effect of carbodiimide (EDC) on the bond stability of etch-and-rinse adhesive systems. Dent Mater 2013; 29 (10) 1040-1047
    CrossrefPubMedSearch in Google Scholar
  • 53 Mazzoni A, Angeloni V, Comba A. et al. Cross-linking effect on dentin bond strength and MMPs activity. Dent Mater 2018; 34 (02) 288-295
    CrossrefPubMedSearch in Google Scholar
  • 54 Mohamed AM, Nabih SM, Wakwak MA. Effect of chitosan nanoparticles on microtensile bond strength of resin composite to dentin: an in vitro study. Braz Dent Sci 2020; 23 (02) 10
    CrossrefSearch in Google Scholar
  • 55 Mosallam R, Younis N, Farouk H, Mosallam O. Effect of green tea and two mulberry leaf extracts on micro-tensile bond strength to dentin. Futur Dent J 2018; 4 (02) 150-155
    CrossrefSearch in Google Scholar
  • 56 Mosallam R, Younis N, Farouk H, Mosallam O. Effect of matrix metalloproteinase inhibitor from mulberry fruit extract on the microtensile bond strength stability: an in vitro study. Egypt Dent J 2019; 65 (01) 541-550
    CrossrefSearch in Google Scholar
  • 57 Ou Q, Hu Y, Yao S, Wang Y, Lin X. Effect of matrix metalloproteinase 8 inhibitor on resin-dentin bonds. Dent Mater 2018; 34 (05) 756-763
    CrossrefPubMedSearch in Google Scholar
  • 58 Paulose NE, Fawzy AS. Effect of carbodiimide on the bond strength and durability of resin-dentin interface. J Adhes Sci Technol 2018; 32 (09) 931-946
    CrossrefSearch in Google Scholar
  • 59 Pedrosa VO, França FMG, Turssi CP. et al. Effects of caffeic acid phenethyl ester application on dentin MMP-2, stability of bond strength and failure mode of total-etch and self-etch adhesive systems. Arch Oral Biol 2018; 94: 16-26
    CrossrefPubMedSearch in Google Scholar
  • 60 Perote LC, Kamozaki MB, Gutierrez NC, Tay FR, Pucci CR. Effect of matrix metalloproteinase-inhibiting solutions and aging methods on dentin bond strength. J Adhes Dent 2015; 17 (04) 347-352
    PubMedSearch in Google Scholar
  • 61 Porto ICCM, Nascimento TG, Oliveira JMS, Freitas PH, Haimeur A, França R. Use of polyphenols as a strategy to prevent bond degradation in the dentin-resin interface. Eur J Oral Sci 2018; 126 (02) 146-158
    CrossrefPubMedSearch in Google Scholar
  • 62 Prasansuttiporn T, Thanatvarakorn O, Mamanee T. et al. Effect of antioxidant/reducing agents on the initial and long-term bonding performance of a self-etch adhesive to caries-affected dentin with and without smear layer-deproteinizing. Int J Adhes Adhes 2020; 102: 102648
    CrossrefSearch in Google Scholar
  • 63 Prasansuttiporn T, Thanatvarakorn O, Tagami J, Foxton RM, Nakajima M. Bonding durability of a self-etch adhesive to normal versus smear-layer deproteinized dentin: effect of a reducing agent and plant-extract antioxidant. J Adhes Dent 2017; 19 (03) 253-258
    PubMedSearch in Google Scholar
  • 64 Ruksaphon K, Pisol S. Efficacy of chlorhexidine and rosmarinic acid to prevent resin/dentine interface degradation. Dent Oral Craniofac Res 2017; 4 (02) 1-9
    CrossrefSearch in Google Scholar
  • 65 Sacramento PA, de Castilho AR, Banzi EC, Puppi-Rontani RM. Influence of cavity disinfectant and adhesive systems on the bonding procedure in demineralized dentin - a one-year in vitro evaluation. J Adhes Dent 2012; 14 (06) 575-583
    PubMedSearch in Google Scholar
  • 66 Sadeghi M, Salehi A, Roberts MW. Effect of chlorhexidine application on dentin bond strength durability of two etch-and-rinse adhesive versus a universal bond system. JDOC 2017; 3 (02) 202
    Search in Google Scholar
  • 67 Santiago SL, Osorio R, Neri JR, Carvalho RM, Toledano M. Effect of the flavonoid epigallocatechin-3-gallate on resin-dentin bond strength. J Adhes Dent 2013; 15 (06) 535-540
    PubMedSearch in Google Scholar
  • 68 Shen J, Xie H, Wang Q, Wu X, Yang J, Chen C. Evaluation of the interaction of chlorhexidine and MDP and its effects on the durability of dentin bonding. Dent Mater 2020; 36 (12) 1624-1634
    CrossrefPubMedSearch in Google Scholar
  • 69 Venigalla BS, Jyothi P, Kamishetty S, Reddy S, Cherukupalli RC, Reddy DA. Resin bond strength to water versus ethanol-saturated human dentin pretreated with three different cross-linking agents. J Conserv Dent 2016; 19 (06) 555-559
    CrossrefPubMedSearch in Google Scholar
  • 70 Xu J, Li M, Wang W. et al. A novel prime-&-rinse mode using MDP and MMPs inhibitors improves the dentin bond durability of self-etch adhesive. J Mech Behav Biomed Mater 2020; 104: 103698
    CrossrefPubMedSearch in Google Scholar
  • 71 Kazemi-Yazdi H, Saeed-Nezhad M, Rezaei S. Effect of chlorhexidine on durability of two self-etch adhesive systems. J Clin Exp Dent 2020; 12 (07) e663-e669
    CrossrefPubMedSearch in Google Scholar
  • 72 Da Silva EM, Glir DH, Gill AW, Giovanini AF, Furuse AY, Gonzaga CC. Effect of chlorhexidine on dentin bond strength of two adhesive systems after storage in different media. Braz Dent J 2015; 26 (06) 642-647
    CrossrefPubMedSearch in Google Scholar
  • 73 Zheng P, Zaruba M, Attin T, Wiegand A. Effect of different matrix metalloproteinase inhibitors on microtensile bond strength of an etch-and-rinse and a self-etching adhesive to dentin. Oper Dent 2015; 40 (01) 80-86
    CrossrefPubMedSearch in Google Scholar
  • 74 Sadek FT, Braga RR, Muench A, Liu Y, Pashley DH, Tay FR. Ethanol wet-bonding challenges current anti-degradation strategy. J Dent Res 2010; 89 (12) 1499-1504
    CrossrefPubMedSearch in Google Scholar
  • 75 Stanislawczuk R, Amaral RC, Zander-Grande C, Gagler D, Reis A, Loguercio AD. Chlorhexidine-containing acid conditioner preserves the longevity of resin-dentin bonds. Oper Dent 2009; 34 (04) 481-490
    CrossrefPubMedSearch in Google Scholar
  • 76 Firouzmandi M, Mohaghegh M, Jafarpisheh M. Effect of silver diamine fluoride on the bond durability of normal and carious dentin. J Clin Exp Dent 2020; 12 (05) e468-e473
    CrossrefPubMedSearch in Google Scholar
  • 77 Giacomini MC, Scaffa P, Chaves LP. et al. Role of proteolytic enzyme inhibitors on carious and eroded dentin associated with a universal bonding system. Oper Dent 2017; 42 (06) E188-E196
    CrossrefPubMedSearch in Google Scholar
  • 78 Sabatini C, Kim JH, Ortiz Alias P. In vitro evaluation of benzalkonium chloride in the preservation of adhesive interfaces. Oper Dent 2014; 39 (03) 283-290
    CrossrefPubMedSearch in Google Scholar
  • 79 Carvalho C, Fernandes FP, Freitas VdaP. et al. Effect of green tea extract on bonding durability of an etch-and-rinse adhesive system to caries-affected dentin. J Appl Oral Sci 2016; 24 (03) 211-217
    CrossrefPubMedSearch in Google Scholar
  • 80 Loguercio AD, Stanislawczuk R, Malaquias P, Gutierrez MF, Bauer J, Reis A. Effect of minocycline on the durability of dentin bonding produced with etch-and-rinse adhesives. Oper Dent 2016; 41 (05) 511-519
    CrossrefPubMedSearch in Google Scholar
  • 81 Mobarak EH. Effect of chlorhexidine pretreatment on bond strength durability of caries-affected dentin over 2-year aging in artificial saliva and under simulated intrapulpal pressure. Oper Dent 2011; 36 (06) 649-660
    CrossrefPubMedSearch in Google Scholar
  • 82 Manso AP, Grande RHM, Bedran-Russo AK. et al. Can 1% chlorhexidine diacetate and ethanol stabilize resin-dentin bonds?. Dent Mater 2014; 30 (07) 735-741
    CrossrefPubMedSearch in Google Scholar
  • 83 Montagner AF, Pereira-Cenci T, Cenci MS. Influence of cariogenic challenge on bond strength stability of dentin. Braz Dent J 2015; 26 (02) 128-134
    CrossrefPubMedSearch in Google Scholar
  • 84 Li K, Sun Y, Tsoi JKH, Yiu CKY. The application of mussel-inspired molecule in dentin bonding. J Dent 2020; 99: 103404
    CrossrefPubMedSearch in Google Scholar
  • 85 Kalagi S, Feitosa SA, Münchow EA. et al. Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive. Dent Mater 2020; 36 (05) 687-697
    CrossrefPubMedSearch in Google Scholar
  • 86 Tekçe N, Tuncer S, Demirci M, Balci S. Do matrix metalloproteinase inhibitors improve the bond durability of universal dental adhesives?. Scanning 2016; 38 (06) 535-544
    CrossrefPubMedSearch in Google Scholar
  • 87 de Moura RR, França FMG, Turssi CP, Basting RT, do Amaral FLB. Effect of different concentrations of green tea extract solutions on bonding durability of etch-and-rinse adhesive system to caries affected dentin. Braz J Oral Sci 2021; 20: e210328-e210328
    CrossrefSearch in Google Scholar
  • 88 Li K, Yao C, Sun Y. et al. Enhancing resin-dentin bond durability using a novel mussel-inspired monomer. Mater Today Bio 2021; 12: 100174
    CrossrefPubMedSearch in Google Scholar
  • 89 Kiuru O, Sinervo J, Vähänikkilä H, Anttonen V, Tjäderhane L. MMP inhibitors and dentin bonding: systematic review and meta-analysis. Int J Dent 2021; 2021: 9949699
    CrossrefPubMedSearch in Google Scholar
  • 90 Gendron R, Grenier D, Sorsa T, Mayrand D. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol 1999; 6 (03) 437-439
    CrossrefPubMedSearch in Google Scholar
  • 91 Collares FM, Rodrigues SB, Leitune VC, Celeste RK, Borba de Araújo F, Samuel SM. Chlorhexidine application in adhesive procedures: a meta-regression analysis. J Adhes Dent 2013; 15 (01) 11-18
    PubMedSearch in Google Scholar
  • 92 Montagner AF, Perroni AP, Corrêa MB, Masotti AS, Pereira-Cenci T, Cenci MS. Effect of pre-treatment with chlorhexidine on the retention of restorations: a randomized controlled trial. Braz Dent J 2015; 26 (03) 234-241
    PubMedSearch in Google Scholar
  • 93 Dutra-Correa M, Saraceni CH, Ciaramicoli MT, Kiyan VH, Queiroz CS. Effect of chlorhexidine on the 18-month clinical performance of two adhesives. J Adhes Dent 2013; 15 (03) 287-292
    PubMedSearch in Google Scholar
  • 94 Favetti M, Schroeder T, Montagner AF, Correa MB, Pereira-Cenci T, Cenci MS. Effectiveness of pre-treatment with chlorhexidine in restoration retention: A 36-month follow-up randomized clinical trial. J Dent 2017; 60: 44-49
    CrossrefPubMedSearch in Google Scholar
  • 95 Sartori N, Stolf SC, Silva SB, Lopes GC, Carrilho M. Influence of chlorhexidine digluconate on the clinical performance of adhesive restorations: a 3-year follow-up. J Dent 2013; 41 (12) 1188-1195
    CrossrefPubMedSearch in Google Scholar
  • 96 Hebling J, Pashley DH, Tjäderhane L, Tay FR. Chlorhexidine arrests subclinical degradation of dentin hybrid layers in vivo. J Dent Res 2005; 84 (08) 741-746
    CrossrefPubMedSearch in Google Scholar
  • 97 Carrilho MR, Geraldeli S, Tay F. et al. In vivo preservation of the hybrid layer by chlorhexidine. J Dent Res 2007; 86 (06) 529-533
    CrossrefPubMedSearch in Google Scholar
  • 98 Hass V, Luque-Martinez IV, Gutierrez MF. et al. Collagen cross-linkers on dentin bonding: Stability of the adhesive interfaces, degree of conversion of the adhesive, cytotoxicity and in situ MMP inhibition. Dent Mater 2016; 32 (06) 732-741
    CrossrefPubMedSearch in Google Scholar
  • 99 Cova A, Breschi L, Nato F. et al. Effect of UVA-activated riboflavin on dentin bonding. J Dent Res 2011; 90 (12) 1439-1445
    CrossrefPubMedSearch in Google Scholar
  • 100 Chiang YS, Chen YL, Chuang SF. et al. Riboflavin-ultraviolet-A-induced collagen cross-linking treatments in improving dentin bonding. Dent Mater 2013; 29 (06) 682-692
    CrossrefPubMedSearch in Google Scholar
  • 101 Heintze SD, Zimmerli B, Zahnmed SM. Relevance of in vitro tests of adhesive and composite dental materials. A review in 3 parts. Part 3: in vitro tests of adhesive systems [in German]. Schweiz Monatsschr Zahnmed 2011; 121 (11) 1024-1040
    PubMedSearch in Google Scholar