Journal Summary: Therapeutic Vaccines for Chronic Hepatitis B—Hope or Hype

Pardhu B. Neelam; Sunil Taneja

doi:10.1055/s-0042-1757604

Journal of Gastrointestinal Infections, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Journal of Gastrointestinal Infections 2022; 12(01): 064-069
DOI: 10.1055/s-0042-1757604

Journal Summary

Journal Summary: Therapeutic Vaccines for Chronic Hepatitis B—Hope or Hype

Pardhu B. Neelam

¹Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

,

Sunil Taneja

²Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

References
1 Pol S. Immunotherapy of chronic hepatitis B by anti HBV vaccine. Biomed Pharmacother 1995; 49 (03) 105-109
2 Wei L, Zhao T, Zhang J. et al. Efficacy and safety of a nanoparticle therapeutic vaccine in patients with chronic hepatitis B: a randomized clinical trial. Hepatology 2022; 75 (01) 182-195
3 Wang W, Zhou X, Bian Y. et al. Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B. Nat Nanotechnol 2020; 15 (05) 406-416
4 Li T, Zehner M, He J. et al. NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells. Int J Nanomedicine 2019; 14: 3503-3516
5 Schijns V, Fernández-Tejada A, Barjaktarović Ž. et al. Modulation of immune responses using adjuvants to facilitate therapeutic vaccination. Immunol Rev 2020; 296 (01) 169-190
6 Boni C, Fisicaro P, Valdatta C. et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007; 81 (08) 4215-4225
7 Asabe S, Wieland SF, Chattopadhyay PK. et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 2009; 83 (19) 9652-9662
8 Mancini-Bourgine M, Fontaine H, Scott-Algara D, Pol S, Bréchot C, Michel ML. Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology 2004; 40 (04) 874-882
9 Boni C, Janssen HLA, Rossi M. et al. Combined GS-4774 and tenofovir therapy can improve HBV-specific T-cell responses in patients with chronic hepatitis. Gastroenterology 2019; 157 (01) 227-241
10 Cavenaugh JS, Awi D, Mendy M, Hill AV, Whittle H, McConkey SJ. Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection. PLoS One 2011; 6 (02) e14626
11 Gane E, Verdon DJ, Brooks AE. et al. Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: a pilot study. J Hepatol 2019; 71 (05) 900-907 Pol S. Immunotherapy of chronic hepatitis B by anti HBV vaccine. Biomedicine & pharmacotherapy. 1995 Jan 1;49(3):105–9