Subscribe to RSS
DOI: 10.1055/s-0042-1757939
Varicoceles: Overview of Treatment from a Radiologic and Surgical Perspective
Abstract
A testicular varicocele is the result of the expansion of the venous pampiniform plexus of the scrotum. Often painless, a significant number of patients experience orchialgia, swelling, testicular atrophy, and abnormalities in spermatic parameters. Treatment of symptomatic varicocele involves a radiologic or surgical intervention to obstruct the reflux of venous drainage. Testicular anatomy, diagnostic evaluation and imaging, options for surgical intervention, and a step-by-step description of retrograde embolization and antegrade scrotal sclerotherapy are discussed. Furthermore, included is an overview of postprocedural management and patient outcomes for radiological interventions, and the most up-to-date evidence on the efficacy of varicocele treatments as well as how they compare to each other.
Authors' Contributions
All authors contributed to the study's conception and design. All authors read and approved the final manuscript.
Ethics Approval
This review was deemed IRB exempt.
Publication History
Article published online:
20 December 2022
© 2022. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Leslie SW, Sajjad H, Siref LE. Varicocele. StatPearls. Published online February 14, 2022. Accessed April 21, 2022 at: https://www.ncbi.nlm.nih.gov/books/NBK448113/
- 2 Paick S, Choi WS. Varicocele and testicular pain: a review. World J Mens Health 2019; 37 (01) 4-11
- 3 Mohammed A, Chinegwundoh F. Testicular varicocele: an overview. Urol Int 2009; 82 (04) 373-379
- 4 Sigalos JT, Pastuszak AW. Chronic orchialgia: epidemiology, diagnosis and evaluation. Transl Androl Urol 2017; 6 (Suppl. 01) S37-S43
- 5 Baigorri BF, Dixon RG. Varicocele: a review. Semin Intervent Radiol 2016; 33 (03) 170-176
- 6 Fang Y, Su Y, Xu J. et al. Varicocele-mediated male infertility: from the perspective of testicular immunity and inflammation. Front Immunol 2021; 12: 729539
- 7 Zhang Y, Zhang W, Wu X. et al. Effect of varicocele on sperm DNA damage: a systematic review and meta-analysis. Andrologia 2022; 54 (01) e14275
- 8 Finelli R, Leisegang K, Kandil H, Agarwal A. Oxidative stress: a comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele. World J Mens Health 2022; 40 (01) 87-103
- 9 Zavattaro M, Ceruti C, Motta G. et al. Treating varicocele in 2018: current knowledge and treatment options. J Endocrinol Invest 2018; 41 (12) 1365-1375
- 10 Binsaleh S, Lo KC. Varicocelectomy: microsurgical inguinal varicocelectomy is the treatment of choice. Can Urol Assoc J 2007; 1 (03) 277-278
- 11 Lopushnyan NA, Walsh TJ. Surgical techniques for the management of male infertility. Asian J Androl 2012; 14 (01) 94-102
- 12 Zambrano Serrano CA, Carvajal Obando A. Surgical treatment for male infertility. Actas Urol Esp (Engl Ed) 2020; 44 (05) 314-320
- 13 Su JS, Farber NJ, Vij SC. Pathophysiology and treatment options of varicocele: an overview. Andrologia 2021; 53 (01) e13576
- 14 Iaccarino V, Venetucci P. Interventional radiology of male varicocele: current status. Cardiovasc Intervent Radiol 2012; 35 (06) 1263-1280
- 15 Sheehan M, Briody H, O'Neill DC. et al. Pain relief after varicocele embolization: the patient's perspective. J Med Imaging Radiat Oncol 2020; 64 (02) 215-219
- 16 Broe MP, Ryan JPC, Ryan EJ. et al. Spermatic vein embolization as a treatment for symptomatic varicocele. Can Urol Assoc J 2021; 15 (11) E569-E573
- 17 Bertolotto M, Freeman S, Richenberg J. et al; Members of the ESUR-SPIWG WG. Ultrasound evaluation of varicoceles: systematic literature review and rationale of the ESUR-SPIWG Guidelines and Recommendations. J Ultrasound 2020; 23 (04) 487-507
- 18 Masson P, Brannigan RE. The varicocele. Urol Clin North Am 2014; 41 (01) 129-144
- 19 Little AF, Lavoipierre AM. Unusual clinical manifestations of the nutcracker syndrome. Australas Radiol 2002; 46 (02) 197-200
- 20 Nagler HM, Grotas AB. Varicocele. In: Lipshultz LI, Howards SS, Niederberger CS. eds. Infertility in the Male. 2009: 331-361
- 21 Shafik A, Bedeir GAM. Venous tension patterns in cord veins. I. In normal and varicocele individuals. J Urol 1980; 123 (03) 383-385
- 22 Lotti F, Maggi M. Ultrasound of the male genital tract in relation to male reproductive health. Hum Reprod Update 2015; 21 (01) 56-83
- 23 Lee J, Binsaleh S, Lo K, Jarvi K. Varicoceles: the diagnostic dilemma. J Androl 2008; 29 (02) 143-146
- 24 Muršić M, Sjekavica I, Šimunović M, Ježek D. The role of ultrasound elastography in the diagnosis of pathologic conditions of testicles and scrotum. Acta Clin Croat 2021; 60 (01) 41-49
- 25 Salama N, Samir M, Blgozah S. Evaluation of normal and varicocele-bearing testes using real-time strain elastography. J Ultrasound Med 2019; 38 (03) 621-627
- 26 Dadpay M, Ghayoumi Zadeh H, Danaeian M, Namdari F, Rezakhaniha B. Evaluation of thermal imaging system of the scrotum in patients with varicocele. Iran J Public Health 2017; 46 (12) 1742-1743
- 27 Freeman S, Bertolotto M, Richenberg J. et al; members of the ESUR-SPIWG WG. Ultrasound evaluation of varicoceles: guidelines and recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for detection, classification, and grading. Eur Radiol 2020; 30 (01) 11-25
- 28 Goldstein M, Gilbert BR, Dicker AP, Dwosh J, Gnecco C. Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique. J Urol 1992; 148 (06) 1808-1811
- 29 Hirsch IH, Abdel-Meguid TA, Gomella LG. Postsurgical outcomes assessment following varicocele ligation: laparoscopic versus subinguinal approach. Urology 1998; 51 (05) 810-815
- 30 Watanabe M, Nagai A, Kusumi N, Tsuboi H, Nasu Y, Kumon H. Minimal invasiveness and effectivity of subinguinal microscopic varicocelectomy: a comparative study with retroperitoneal high and laparoscopic approaches. Int J Urol 2005; 12 (10) 892-898
- 31 Al-Kandari AM, Shabaan H, Ibrahim HM, Elshebiny YH, Shokeir AA. Comparison of outcomes of different varicocelectomy techniques: open inguinal, laparoscopic, and subinguinal microscopic varicocelectomy: a randomized clinical trial. Urology 2007; 69 (03) 417-420
- 32 Ramasamy R, Schlegel PN. Microsurgical inguinal varicocelectomy with and without testicular delivery. Urology 2006; 68 (06) 1323-1326
- 33 Yuan R, Zhuo H, Cao D, Wei Q. Efficacy and safety of varicocelectomies: a meta-analysis. Syst Biol Reprod Med 2017; 63 (02) 120-129
- 34 Wang J, Xia SJ, Liu ZH. et al. Inguinal and subinguinal micro-varicocelectomy, the optimal surgical management of varicocele: a meta-analysis. Asian J Androl 2015; 17 (01) 74-80
- 35 Marmar JL. The evolution and refinements of varicocele surgery. Asian J Androl 2016; 18 (02) 171-178
- 36 Çayan S, Shavakhabov S, Kadioğlu A. Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. J Androl 2009; 30 (01) 33-40
- 37 Favard N, Moulin M, Fauque P. et al. Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate. Quant Imaging Med Surg 2015; 5 (06) 806-814
- 38 Kandarpa K, Machan L, Durham J. Handbook of Interventional Radiologic Procedures. 5th ed.. Lippincott Williams & Wilkins; 2016
- 39 Keefe NA, Haskal ZJ, Park AW, Angle JF. IR Playbook: A Comprehensive Introduction to Interventional Radiology. 2018: 1-543
- 40 Tauber R, Johnsen N. Antegrade scrotal sclerotherapy for the treatment of varicocele: technique and late results. J Urol 1994; 151 (02) 386-390
- 41 Crestani A, Giannarini G, Calandriello M. et al. Antegrade scrotal sclerotherapy of internal spermatic veins for varicocele treatment: technique, complications, and results. Asian J Androl 2016; 18 (02) 292-295
- 42 Ficarra V, Sarti A, Novara G. et al. Modified antegrade scrotal sclerotherapy in adolescent patients with varicocele. J Pediatr Surg 2004; 39 (07) 1034-1036
- 43 Tauber R, Pfeiffer D. Surgical atlas varicocele: antegrade scrotal sclerotherapy. BJU Int 2006; 98 (06) 1333-1344
- 44 Fulcoli V, Costa G, Gigli F, Laurini L. Ischemic necrosis of the sigmoid colon after antegrade sclerotherapy of idiopathic varicocele: a case report. Urologia 2013; 80 (02) 162-164
- 45 Beddy P, Geoghegan T, Browne RF, Torreggiani WC. Testicular varicoceles. Clin Radiol 2005; 60 (12) 1248-1255
- 46 Nabi G, Asterlings S, Greene DR, Marsh RL. Percutaneous embolization of varicoceles: outcomes and correlation of semen improvement with pregnancy. Urology 2004; 63 (02) 359-363
- 47 Barbalias GA, Liatsikos EN, Nikiforidis G, Siablis D. Treatment of varicocele for male infertility: a comparative study evaluating currently used approaches. Eur Urol 1998; 34 (05) 393-398
- 48 Kim J, Shin JH, Yoon HK. et al. Persistent or recurrent varicocoele after failed varicocoelectomy: outcome in patients treated using percutaneous transcatheter embolization. Clin Radiol 2012; 67 (04) 359-365
- 49 Qiu D, Shi Q, Pan L. Efficacy of varicocelectomy for sperm DNA integrity improvement: a meta-analysis. Andrologia 2021; 53 (01) e13885
- 50 Wang Q, Yu Y, Liu Y, Wang L. Outcome of varicocelectomy on different degrees of total motile sperm count: a systematic review and meta-analysis. Syst Biol Reprod Med 2019; 65 (06) 430-436
- 51 Majzoub A, ElBardisi H, Covarrubias S. et al. Effect of microsurgical varicocelectomy on fertility outcome and treatment plans of patients with severe oligozoospermia: an original report and meta-analysis. Andrologia 2021; 53 (06) e14059
- 52 Persad E, O'Loughlin CAA, Kaur S. et al. Surgical or radiological treatment for varicoceles in subfertile men. Cochrane Database Syst Rev 2021; 4 (04) CD000479
- 53 Birowo P, Tendi W, Widyahening IS, Atmoko W, Rasyid N. The benefits of varicocele repair for achieving pregnancy in male infertility: a systematic review and meta-analysis. Heliyon 2020; 6 (11) e05439
- 54 Wang X, Chen T, Qiu J, Wu H, Chen X, Xuan X. Effects of primary varicocele and related surgery in male infertility: a meta-analysis. Front Surg 2020; 7: 586153
- 55 Lira Neto FT, Roque M, Esteves SC. Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis. Fertil Steril 2021; 116 (03) 696-712
- 56 Yan S, Shabbir M, Yap T. et al. Should the current guidelines for the treatment of varicoceles in infertile men be re-evaluated?. Hum Fertil (Camb) 2021; 24 (02) 78-92
- 57 Motta A, Caltabiano G, Pizzarelli M. et al. Varicocele, conventional laparoscopic ligation versus occluding balloon embolization. Radiol Med (Torino) 2019; 124 (05) 438-443
- 58 Shlansky-Goldberg RD, VanArsdalen KN, Rutter CM. et al. Percutaneous varicocele embolization versus surgical ligation for the treatment of infertility: changes in seminal parameters and pregnancy outcomes. J Vasc Interv Radiol 1997; 8 (05) 759-767
- 59 Bou Nasr E, Binhazzaa M, Almont T, Rischmann P, Soulie M, Huyghe E. Subinguinal microsurgical varicocelectomy vs. percutaneous embolization in infertile men: prospective comparison of reproductive and functional outcomes. Basic Clin Androl 2017; 27 (01) 11
- 60 Silay MS, Hoen L, Quadackaers J. et al. Treatment of varicocele in children and adolescents: a systematic review and meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel. Eur Urol 2019; 75 (03) 448-461
- 61 Qiangzhao L, Xiaofeng Z, Fenghai Z, Xinsheng X, Shijun L, Qiong L. Comparing radiological and surgical treatments for varicocele: a systematic review and meta-analysis. J Vasc Interv Radiol (Published online March 2022)