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J Neurol Surg A Cent Eur Neurosurg 2023; 84(06): 513-520
DOI: 10.1055/s-0042-1758121
Original Article

Pain Relief and Safety of Microwave Ablation Combined with Percutaneous Vertebroplasty for Vertebral Metastasis: A Pilot Study

Ting-Ye Hu
1   Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Gan Zhang
2   Department of General Surgery, Anhui Hanbo Group Hospital, Chuzhou, Anhui, China
,
Hong Ye
3   Department of Orthopedics, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Cheng-Ling An
4   Digital Subtraction Angiography, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Kai Wang
1   Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Lei Xia
1   Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Xiao-Xing Zhou
1   Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Shan-Shan Zhang
1   Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
,
Yu-He Lu
1   Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China
› Author Affiliations Funding This research is supported by the Chuzhou Science and Technology Bureau of Anhui Provincial Key research and development projects in the field of rural and social development (2018ZN010), Key Research and Development Program of Anhui Province (2022e07020068), and Provincial Quality Engineering Project of Higher Education in Anhui Province in 2020 (2020dsgzs26).
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Abstract

Background We investigate the pain relief and safety of microwave ablation (MWA) combined with percutaneous vertebroplasty (PVP) in the treatment of metastatic vertebral tumors.

Methods This prospective pilot study enrolled patients with metastatic vertebral tumors treated between January 2018 and October 2019. The participants were randomized to the PVP and MWA + PVP groups. Clinical parameters, pain visual analog scale (VAS), analgesic use scores (AUS), and quality-of-life score (QLS) were compared between groups.

Results Sixty-seven participants were enrolled (PVP: n = 35; MWA + PVP: n = 32). There were no differences in bone cement injection volume, extravasation, and X-ray exposure time between the two groups (p > 0.05), but treatment costs were higher for the MWA + PVP group (26,418 ± 194 vs. 15,606 ± 148 yuan; p < 0.05). There were no significant improvements in VAS from baseline to 24 hours, 72 hours, 7 days, 1 month, and 3 months in the two groups (p > 0.05); at 6 and 12 months after the operation, the improvement from baseline was significant in the two groups (p < 0.05). The VAS was lower at 6 months (2.7 ± 0.7 vs. 3.2 ± 0.7) and 12 months (3.5 ± 0.8 vs. 4.0 ± 0.7) in the MWA + PVP group (both p < 0.01 vs. PVP). The AUS and QLS were improved with PVP at 6 and 12 months (p < 0.05) and with MWA + PVP at 12 months (p < 0.05). The AUS was lower at 6 and 12 months in the MWA + PVP group (p < 0.05 vs. PVP).

Conclusion MWA combined with PVP might be a safe and effective palliative treatment for pain from metastatic vertebral tumors.

Keywords

vertebra - metastasis - microwave ablation - percutaneous vertebroplasty - pain


Publication History

Received: 14 February 2022

Accepted: 28 June 2022

Article published online:
09 December 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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