Effect of hyssop syrup on syndrome-differentiated mild to moderate asthma: A pilot clinical trial

Asthma is one of the most common diseases of respiratory system. Hyssopus officinalis L. is a medicinal herb that have shown anti-asthmatic effects. In this study, efficacy of hyssop in mild to moderate asthma was investigated considering the phenotype of the patients. It was a randomized triple-blind placebo-controlled trial on 60 mild-to moderate asthmatic patients. Participants were randomized to receive either hyssop syrup (5 ml twice daily containing 6 g Hyssopus officinalis L. extract) or plain sugar syrup (5 ml twice daily) for 4 weeks as adjuvant to routine treatment. Asthma Control Test (ACT), pulmonary function tests, Expert Panel Report 3 (EPR3) and wheezing severity were considered as outcome measures. A significant improvement was observed in forced expiratory volume in 1 second (FEV1), ACT (at 4th week), peak expiratory flow (PEF), maximal expiratory flow rate 25 – 75 (MEF25-75%), and wheezing severity in the patients with productive cough in hyssop group. However, those with dry cough got worse regarding these indices. Results of this trial revealed the importance of syndrome differentiation in asthmatic patients according to their specific phenotype in order to increase the accuracy of treatment and response rate. Future trials are guaranteed to approve this method of case selection in asthma treatment

Keywords: Asthma; Hyssopus officinalis; Persian Medicine; Randomized Controlled Trial; Respiratory System; Syndrom Differentiation

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Artikel online veröffentlicht:
12. Dezember 2022