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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(04): e636-e644
DOI: 10.1055/s-0042-1759605
Original Research

Does the Number of Stimuli Influence the Formation of the Endogenous Components of the Event-Related Auditory Evoked Potentials?

Yorran Marques de Oliveira 
1   Speech-language pathology and audiology Division, Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto Ringgold Standard Institution, Ciências da Saúde, Ribeirão Preto, SP, Brazil
,
Victor Goiris Calderaro 
1   Speech-language pathology and audiology Division, Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto Ringgold Standard Institution, Ciências da Saúde, Ribeirão Preto, SP, Brazil
,
Eduardo Tanaka Massuda 
2   Department of Ophthalmology, Otolaryngology and Head and Neck Surgery, Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto Ringgold Standard Institution, Ribeirão Preto, SP, Brazil
,
Sthella Zanchetta 
1   Speech-language pathology and audiology Division, Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto Ringgold Standard Institution, Ciências da Saúde, Ribeirão Preto, SP, Brazil
,
Humberto de Oliveira Simões 
3   Speech-language pathology and audiology Sector, Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto Ringgold Standard Institution, Ribeirão Preto, SP, Brazil
› Author Affiliations Funding The author(s) received no financial support for the research.
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Abstract

Introduction The number of stimuli is important to determine the quality of auditory evoked potential records. However, there is no consensus on that number in studies, especially in the sample studied.

Objectives To investigate the influence of the number of rare stimuli on forming N2 and P3 components, with different types of acoustic stimuli.

Methods Cross-sectional, descriptive, comparative study, approved by the ethics committee of the institution. The sample comprised 20 normal hearing adults of both sexes, aged 18 to 29 years old, with normal scores in the mental state examination and auditory processing skills. The event-related auditory evoked potentials were performed with nonverbal (1 kHz versus 2 kHz) and verbal stimuli (/BA/ versus /DA/). The number of rare stimuli varied randomly in the recordings, with 10, 20, 30, 40, and 50 presentations.

Results P3 latency was significantly higher for nonverbal stimuli with 50 rare stimuli. N2 latency did not show any difference between the type and number of stimuli. The absolute P3 and N2-P3 amplitudes showed significant differences for both types of stimuli, with higher amplitude for 10 rare stimuli, in contrast with the other ones. The linear tendency test indicated significance only for the amplitude – as the number of rare stimuli increased, the amplitude tended to decrease.

Conclusion The components were identifiable in the different numbers of rare stimuli and types of stimuli. The P3 and N2-P3 latency and amplitude increased with fewer verbal and nonverbal stimuli. Recording protocols must consider the number of rare stimuli.

Keywords

evoked potentials - P300 component - hearing - electrophysiology - auditory cortex - healthy volunteers


Publication History

Received: 17 June 2022

Accepted: 12 September 2022

Article published online:
06 October 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Schochat E. Avaliação eletrofisiológica da audição. In: Ferreira LP, Befi-Lopes DM, Limongi SCO. (eds.) Tratado de Fonoaudiologia. São Paulo: Rocca; 2004: 656-9
    Search in Google Scholar
  • 2 Hall III J. New handbook of auditory evoked responses. Boston: Allyn e Bacon; 2007
    Search in Google Scholar
  • 3 McPherson DL. Late potentials of the auditory system. San Diego: Singular Publishing Group; 1996
    Search in Google Scholar
  • 4 Massa CGP, Rabelo CM, Matas CG, Schochat E, Samelli AG. P300 com estímulo verbal e não verbal em adultos normo-ouvintes. Rev Bras Otorrinolaringol (Engl Ed) 2011; 77: 686-690
    Search in Google Scholar
  • 5 Cóser PL. P300. In: Grasel S, Beck R. (eds.) Eletrofisiologia - Vias Auditivas e Vestibulares, Monitoramento Intraoperatório. Rio de Janeiro: Thieme Revinter; 2020
    Search in Google Scholar
  • 6 Frizzo A, Reis A. Potencial evocado auditivo de longa latência: parâmetros técnicos. In: Menezes P, Andrade K, Frizzo A, Carnaúba A, Lins O. (eds.) Tratado de Eletrofisiologia para a Audiologia. Ribeirão Preto: Book Toy; 2018: 129-37
    Search in Google Scholar
  • 7 Polich J, Starr A. Middle-, late-, and long-latency auditory evoked potentials. In: Moore E. (ed.) Bases of auditory brain-stem evoked responses. New York: Grune and Stratton; 1983: 345-61
    Search in Google Scholar
  • 8 Samson F, Zeffiro TA, Toussaint A, Belin P. Stimulus complexity and categorical effects in human auditory cortex: an activation likelihood estimation meta-analysis. Front Psychol 2011; 1: 241
    CrossrefPubMedSearch in Google Scholar
  • 9 Martin BA, Tremblay KL, Korczak P. Speech evoked potentials: from the laboratory to the clinic. Ear Hear 2008; 29 (03) 285-313
    CrossrefPubMedSearch in Google Scholar
  • 10 Oppitz SJ, Didoné DD, Silva DD. et al. Long-latency auditory evoked potentials with verbal and nonverbal stimuli. Rev Bras Otorrinolaringol (Engl Ed) 2015; 81 (06) 647-652
    CrossrefPubMedSearch in Google Scholar
  • 11 Portin R, Kovala T, Polo-Kantola P, Revonsuo A, Müller K, Matikainen E. Does P3 reflect attentional or memory performances, or cognition more generally?. Scand J Psychol 2000; 41 (01) 31-40
    CrossrefPubMedSearch in Google Scholar
  • 12 Kececi H, Degirmenci Y, Atakay S. Habituation and dishabituation of P300. Cogn Behav Neurol 2006; 19 (03) 130-134
    CrossrefPubMedSearch in Google Scholar
  • 13 Chi MH, Chu CL, Lee IH. et al. Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring. Clin Psychopharmacol Neurosci 2019; 17 (04) 509-516
    CrossrefPubMedSearch in Google Scholar
  • 14 Gupta S, Prasad A, Singh R, Gupta G. Auditory and Visual P300 Responses in Early Cognitive Assessment of Children and Adolescents with Epilepsy. J Pediatr Neurosci 2020; 15 (01) 9-14
    PubMedSearch in Google Scholar
  • 15 Avisar A, Shalev L. Sustained attention and behavioral characteristics associated with ADHD in adults. Appl Neuropsychol 2011; 18 (02) 107-116
    CrossrefPubMedSearch in Google Scholar
  • 16 Folstein M, Folstein S, White T. et al. MMSE-2 Mini Exame do Estado Mental segunda edição: Hogrefe, 2018
  • 17 Auditec. Evaluation manual of pitch pattern sequence and duration pattern sequence. Saint Louis: Auditec; 1997
    Search in Google Scholar
  • 18 Keith R. Random Gap Detection Test. Saint Louis: Auditec; 2000
    Search in Google Scholar
  • 19 Corazza MCA. Avaliação do processamento auditivo central em adultos: teste de padrões tonais auditivos de freqüência e teste de padrões tonais auditivos de duração. 1998
    PubMedSearch in Google Scholar
  • 20 Pereira LD, Schochat E. Testes auditivos comportamentais para avaliação do processamento auditivo central. Pro Fono 2011
    PubMedSearch in Google Scholar
  • 21 Duncan-Johnson CC, Donchin E. On quantifying surprise: the variation of event-related potentials with subjective probability. Psychophysiology 1977; 14 (05) 456-467
    CrossrefPubMedSearch in Google Scholar
  • 22 Donchin EKM, Kutas M, Johnson R, Tterning RI. Graded changes in evoked response (P300) amplitude as a function of cognitive activity. Percept Psychophys 1973; 14 (02) 319-324
    CrossrefSearch in Google Scholar
  • 23 Musiek F, Chermak G. Handbook of (Central) Auditory Processing Disorder, Volume 1: Auditory Neuroscience and Diagnosis. San Diego, CA: Plural Publishing Inc.; 2013
    Search in Google Scholar
  • 24 Mendonça EBS, Muniz LF, Leal MdC, Diniz AdS. Aplicabilidade do teste padrão de frequência e P300 para avaliação do processamento auditivo. Rev Bras Otorrinolaringol (Engl Ed) 2013; 79: 512-521
    CrossrefPubMedSearch in Google Scholar
  • 25 Alvarenga KF, Vicente LC, Lopes RCF. et al. Influência dos contrastes de fala nos potenciais evocados auditivos corticais. Rev Bras Otorrinolaringol (Engl Ed) 2013; 79: 336-341
    CrossrefPubMedSearch in Google Scholar
  • 26 Schantz SL, Brown WS. P300 Latency and Cognitive Ability. Clinical perspectives in the management of Down Syndrome: Springer, 1990: 139–46
  • 27 Szuromi B, Czobor P, Komlósi S, Bitter I. P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis. Psychol Med 2011; 41 (07) 1529-1538
    CrossrefPubMedSearch in Google Scholar