COVID-19 Vaccines—All You Want to Know

Akira A. Shishido; Ashley H. Barnes; Shivakumar Narayanan; Joel V. Chua

doi:10.1055/s-0042-1759779

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Semin Respir Crit Care Med 2023; 44(01): 143-172
DOI: 10.1055/s-0042-1759779

Review Article

COVID-19 Vaccines—All You Want to Know

Akira A. Shishido

¹Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland

²Division of Infectious Diseases, Virginia Commonwealth University, Richmond, Virginia

,

Ashley H. Barnes

¹Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland

,

Shivakumar Narayanan

¹Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland

,

Joel V. Chua

¹Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland

› Author Affiliations Funding None.

› Further Information

Abstract
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Abstract

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has led to an unprecedented public health crisis. The collective global response has led to production of multiple safe and effective vaccines utilizing novel platforms to combat the virus that have propelled the field of vaccinology forward. Significant challenges to universal vaccine effectiveness remain, including immune evasion by SARS-CoV-2 variants, waning of immune response, inadequate knowledge of correlates of protection, and dosing in special populations. This review serves as a detailed evaluation of the development of the current SARS-CoV-2 vaccines, their effectiveness, and challenges to their deployment as a preventive tool.

Keywords

COVID-19 - SARS-CoV-2 - vaccines - variants - immunity

Authors' Contributions

A.A.S. and A.H.B. wrote the initial draft of the manuscript. S.N. and J.V.C. supervised creation of the manuscript and reviewed and edited the manuscript. A.A.S. created the illustrations. All authors reviewed and approved the final draft of the manuscript.

Publication History

Article published online:
16 January 2023

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

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COVID-19 Vaccines—All You Want to Know

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