Abstract
Background Increased intraocular pressure (IOP) likely secondary to an activated oculo-trigeminal
reflex network is an important issue following subarachnoid hemorrhage (SAH). The
relationship between the IOP and trigeminal ganglion (TGG) following experimental
SAH was investigated in this study.
Methods Twenty-three rabbits were used in this study. Five rabbits (n = 5) were used as the control group, another 5 as the sham group (n = 5), and the remaining 13 (n = 13) as the study group. The study group was further divided into two groups of
animals with mild (n = 6) and severe (n = 7) TGG degeneration. The IOP values were recorded. After 2 weeks, the animals were
decapitated. The mean degenerated neuron density of TGGs was estimated by stereological
methods and analyzed statistically.
Results The average IOP values were 11.85, 14.12, and 21.45 mm Hg in the control (n = 5), sham (n = 5), and study (n = 13) groups, respectively. The mean degenerated neuron density was 34, 237, and
3,165 mm3 in the control, sham, and study groups, respectively.
Conclusion According to the findings of this study, the experimental SAH leads to changes in
IOP by affecting the TGG. By predicting and preventing IOP elevation in the setting
of SAH, our findings will shed light on secondary sequelae such as glaucoma and irreversible
blindness.
Keywords
trigeminal ganglion - intraocular pressure - subarachnoid hemorrhage
