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DOI: 10.1055/s-0043-100382
Antichlamydial Dimeric Indole Derivatives from Marine Actinomycete Rubrobacter radiotolerans
Publikationsverlauf
received 26. September 2016
revised 19. Dezember 2016
accepted 29. Dezember 2016
Publikationsdatum:
17. Januar 2017 (online)
![](https://www.thieme-connect.de/media/plantamedica/201709/lookinside/thumbnails/10-1055-s-0043-100382_pma0784-1.jpg)
Abstract
Chlamydiae are widely distributed pathogens of human populations, which can lead to serious reproductive and other health problems. In our search for novel antichlamydial metabolites from marine derived-microorganisms, one new (1) and two known (2, 3) dimeric indole derivatives were isolated from the sponge-derived actinomycete Rubrobacter radiotolerans. The chemical structures of these metabolites were elucidated by NMR spectroscopic data as well as CD calculations. All three metabolites suppressed chlamydial growth in a concentration-dependent manner. Among them, compound 1 exhibited the most effective antichlamydial activity with IC50 values of 46.6 ~ 96.4 µM in the production of infectious progeny. Compounds appeared to target the mid-stage of the chlamydial developmental cycle by interfering with reticular body replication, but not directly inactivating the infectious elementary body.
Key words
Chlamydia - dimeric indole - sponges - actinomycete - Rubrobacter radiotolerans - antichlamydial* These two authors contributed equally to this work.
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