Four New Xanthones from Cratoxylum cochinchinense and Their In Vitro Antiproliferative Effects

Chihiro Ito; Takuya Matsui; Ai Niimi; Hugh T.-W. Tan; Masataka Itoigawa

doi:10.1055/s-0043-102510

Planta Medica, Inhaltsverzeichnis

Planta Med 2017; 83(09): 812-818
DOI: 10.1055/s-0043-102510

Natural Product Chemistry and Analytical Studies

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Four New Xanthones from Cratoxylum cochinchinense and Their In Vitro Antiproliferative Effects

Chihiro Ito

¹Faculty of Pharmacy, Meijo University, Nagoya, Japan

,

Takuya Matsui

¹Faculty of Pharmacy, Meijo University, Nagoya, Japan

²Department of Physiology, Aichi Medical University, Nagakute, Japan

,

Ai Niimi

¹Faculty of Pharmacy, Meijo University, Nagoya, Japan

,

Hugh T.-W. Tan

³Department of Botany, National University of Singapore, Singapore, Singapore

,

Masataka Itoigawa

⁴School of Sport and Health Science, Tokai Gakuen University, Miyoshi, Japan

› Institutsangaben

Abstract

The study of the chemical constituents of branches and twigs of Cratoxylum cochinchinense collected in Singapore led to the isolation and structural elucidation of four new xanthones, named cratoxanthone A (1), B (2), C (3), and D (4), together with six known xanthones (5–10) and one known dihydroanthracenone (11). Eight xanthones (including 1 and 2) and 11 were tested for their antiproliferative activity in three human carcinoma cell lines (lung adenocarcinoma A549, colorectal carcinoma Colo205, and epidermoid carcinoma KB) and a human acute lymphoblastic leukemia B cell line (NALM-6), and the mitochondrial membrane potential was determined in KB cells. New xanthones 1 and 2 attenuated NALM-6 cell proliferation with IC₅₀ values of 17.78 and 8.27 µM, respectively. Furthermore, KB cells treated with these compounds had significantly decreased mitochondrial membrane potentials. Notably, the proliferation of A549 cells was specifically inhibited by 11, but not the xanthones.

Key words

Cratoxylum cochinchinense - Hypericaceae - xanthones - dihydroanthracenone - antiproliferative activity

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Referenzen

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