Leptin and its Receptors in Human Placenta of Small, Adequate, and Large for Gestational Age Newborns

Maria-Luisa Lazo-de-la-Vega-Monroy; Martha I. González-Domínguez; Silvio Zaina; Myrna Sabanero; Leonel Daza-Benítez; Juan Manuel Malacara; Gloria Barbosa-Sabanero

doi:10.1055/s-0043-103345

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2017; 49(05): 350-358
DOI: 10.1055/s-0043-103345

Endocrine Care

Leptin and its Receptors in Human Placenta of Small, Adequate, and Large for Gestational Age Newborns

Maria-Luisa Lazo-de-la-Vega-Monroy

¹Health Sciences Division, Medical Sciences Department, University of Guanajuato, Campus Leon, Mexico, 20 de Enero 929 Col, Obregon, Leon Guanajuato, Mexico

,

Martha I. González-Domínguez

¹Health Sciences Division, Medical Sciences Department, University of Guanajuato, Campus Leon, Mexico, 20 de Enero 929 Col, Obregon, Leon Guanajuato, Mexico

²Universidad de la Cienega del Estado de Michoacan de Ocampo, Trayectoria de Ingenieria en Nanotecnologia, Sahuayo, Michoacan, Mexico

,

Silvio Zaina

¹Health Sciences Division, Medical Sciences Department, University of Guanajuato, Campus Leon, Mexico, 20 de Enero 929 Col, Obregon, Leon Guanajuato, Mexico

,

Myrna Sabanero

³UMAE No. 48 IMSS, Research Department, Leon, Av. Mexico y Paseo de los Insurgentes Col, Los Paraisos CP, Leon, Guanajuato, Mexico

,

Leonel Daza-Benítez

⁴Natural and Exact Sciences Division, Biology Department, University of Guanajuato, Campus Guanajuato, Noria Alta s/n, Guanajuato, Mexico

,

Juan Manuel Malacara

¹Health Sciences Division, Medical Sciences Department, University of Guanajuato, Campus Leon, Mexico, 20 de Enero 929 Col, Obregon, Leon Guanajuato, Mexico

,

Gloria Barbosa-Sabanero

¹Health Sciences Division, Medical Sciences Department, University of Guanajuato, Campus Leon, Mexico, 20 de Enero 929 Col, Obregon, Leon Guanajuato, Mexico

› Institutsangaben

Abstract

Abstarct

Alterations in birth weight impact postnatal outcome and adult metabolic health. Therefore, fetal growth regulation is crucial for preventing chronic metabolic diseases. Leptin has been suggested to play an important role in placental and fetal growth, albeit its specific mechanisms of action have not been elucidated. The aim of this study was to analyze leptin concentrations in placenta, cord blood, and maternal blood of SGA, AGA, and LGA (small, adequate and large for gestational age, respectively) newborns, as well as placental leptin receptor (LEPRa and LEPRb) protein expression. We performed a cross-sectional comparative study in 3 groups of healthy mothers and their term newborns at delivery (SGA, AGA, and LGA, n=20 per group). Placental, maternal blood, and cord blood leptin content were measured by ELISA. Placental LEPRa and LEPRb protein expression were determined by Western Blot. Maternal leptin concentrations correlated positively with maternal weight before and at the end of gestation, without differences between groups. Cord leptin is higher in LGA and lower in SGA, whereas placental leptin is higher in SGA. Placental leptin was inversely correlated with placental weight, independently from maternal weight and gestational age. Both LEPRa and LEPRb expression are lower in SGA, while LEPRa positively correlated with placental weight and birthweight. The current findings indicate that placental leptin and its receptors are differentially expressed in SGA, AGA, and LGA newborns. We suggest that placental leptin and LEPR protein expression may influence placental growth and thus, birth weight.

Key words

placenta - leptin receptor - leptin - birth weight

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Referenzen

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