Molekulare Entzündungsdiagnostik im 21. Jahrhundert – der Weg zu mehr Spezifität und individualisierter Medizin?

Caroline Bouter

doi:10.1055/s-0043-105005

Der Nuklearmediziner, Inhaltsverzeichnis

Der Nuklearmediziner 2017; 40(02): 148-164
DOI: 10.1055/s-0043-105005

Entzündungsdiagnostik

Molekulare Entzündungsdiagnostik im 21. Jahrhundert – der Weg zu mehr Spezifität und individualisierter Medizin?

Molecular Diagnostics of Infection and Inflammation in the 21st Century – enroute to more Specificity and individulised Medicine?

Caroline Bouter

Abteilung Nuklearmedizin, Universitätsmedizin Göttingen, Göttingen

› Institutsangaben

Abstract

Zusammenfassung

Die Diagnostik entzündlicher Erkrankungen stellt nach wie vor eine große klinische Herausforderung dar. Die molekulare Bildgebung erlaubt die Darstellung eines entzündlichen Geschehens in vivo, wobei pathophysiologische Veränderungen in einer frühen Phase des Entzündungsprozesses noch vor dem Auftreten anatomischer Veränderungen detektierbar sind. Es stehen verschiedene nuklearmedizinische Tracer zur Entzündungsdiagnostik mittels Gammakamera und PET/CT mit unterschiedlicher Spezifität zur Darstellung einer Entzündung zur Verfügung.

Der vorliegende Artikel befasst sich schwerpunktmäßig mit den Entwicklungen der nuklearmedizinischen Entzündungsdiagnostik in den letzten 16 Jahren. Auf dem Weg zu mehr Spezifität und Individualität in der Bildgebung akuter und chronischer Entzündungen werden erste Ergebnisse über die klinische Anwendung neue Tracer, mit ihren jeweiligen Vorzügen und Limitationen, vorgestellt.

Abstract

Diagnosis of inflammatory diseases still displays a major clinical issue. Molecular imaging is able to identify infection and inflammation in an early stage before the occurrence of anatomical changes. A variety of radiolabeled tracers for imaging infection and inflammation has been developed for SPECT and PET imaging so far.

This article mainly reviews the development of diagnostics in acute and chronic inflammation in nuclear medicine within the last 16 years. It gives an overview of first clinical results of newly developed radiotracers and their advantages and limitations on the way to more specificity and individualized diagnostics.

Schlüsselwörter

Entzündung - PET/CT - SPECT - SPECT/CT - Tracer

Keywords

Infection - Inflammation - PET/CT - SPECT - Tracer

Volltext

Referenzen

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