Subscribe to RSS
DOI: 10.1055/s-0043-105848
Die Transkatheter Aortenklappenimplantation (TAVI)
Lehren aus randomisierten Studien und RegisternTranscatheter Aortic valve implantationPublication History
Publication Date:
24 April 2017 (online)

Die TAVI („transcatheter aortic valve implantation“) hat bei der Behandlung der symptomatischen Aortenklappenstenose in den letzten Jahren zunehmend an Bedeutung gewonnen. Randomisiert-kontrollierte Studien haben die Wirksamkeit bei inoperablen Patienten sowie bei Patienten mit einem mittleren und hohen perioperativen Risiko nachweisen können.
Registerstudien haben eine zunehmende Verbreitung der TAVI sowie eine deutliche Reduktion der Komplikationsraten in den letzten Jahren belegen können.
Transcatheter aortic valve implantation (TAVI) is gaining importance for the treatment of symptomatic aortic stenosis. Through randomized controlled trials TAVI has been proven to be effective in inoperable patients as well as in patients with intermediate and high perioperative risk. Registry studies have documented a rapid increase in TAVI use and a significant reduction in complication rates in recent years.
-
Literatur
- 1 Leon MB, Smith CR, Mack M et al PARTNER Trial Investigators. Transcatheter aorticvalve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 2010; 363: 1597-1607
- 2 Adams DH, Popma JJ, Reardon MJ et al Transcatheter aortic-valve replacement with a self- expanding prosthesis. N Engl J Med 2014; 370: 1790-1798
- 3 Smith CR, Leon MB, Mack MJ et al PARTNER Trial Investigators. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 2011; 364: 2187-2198
- 4 Leon MB, Smith CR, Mack MJ et al PARTNER 2 Investigators. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl JMed 2016; 374: 1609-1620
- 5 Thourani VH, Kodali S, Makkar RR et al Transcatheter aortic valve replacement versus surgical valve replacement in intermediaterisk patients: a propensity score analysis. Lancet 2016; 387: 2218-2225
- 6 Thyregod HG, Steinbrüchel DA, Ihlemann N et al Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve stenosis: 1-year results from the all-comers NOTION randomized clinical trial. J Am Coll Cardiol 2015; 65: 2184-2194
- 7 Kuck KH, Eggebrecht H, Elsässer A et al Qualitätskriterien zur Durchführung der kathetergestützen Aortenklappenimplantation (TAVI). Aktualisierung des Positionspapiers der Deutschen Gesellschaft für Kardiologie. Kardiologe 2016; 10: 282-300
- 8 Hamm CW, Möllmann H, Holzhey D et al The German Aortic Valve Registry (GARY): in-hospital outcome. Eur Heart J 2014; 35: 1588-1598
- 9 Möllmann H, Bestehorn K, Bestehorn M et al In-hospital Outcome of Transcatheter vs. Surgical Aortic Valve Replacement in Patients with Aortic Valve Stenosis. Clin Res Cardiol 2016; 105: 553-559
- 10 Walther T, Hamm CW, Schuler G et al Perioperative Results and Complications in 15,964 Transcatheter Aortic Valve Replacements: Prospective Data From the GARY Registry. J Am Coll Cardiol 2015; 65: 2173-2180
- 11 Gaede L, Kim WK, Blumenstein J et al Temporal trends in transcatheter and surgical aortic valve replacement : An analysis of aortic valve replacements in Germany during 2012-2014. Herz 2016 Aug 5. [Epub ahead of print]
- 12 Khatri PJ, Webb JG, Rodes-Cabau J et al Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies. Ann Intern Med 2013; 158: 35-46
- 13 Kapadia SR, Leon MB, Makkar RR et al 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet 2015; 385: 2485-2491