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Horm Metab Res 2017; 49(08): 572-579
DOI: 10.1055/s-0043-107835
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Aromatase on the Reproductive Function of Obese Males

Xiaolin Xu
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Mingqi Sun
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Jifeng Ye
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
2   Department of Endocrinology and Metabolism, The Second People’s Hospital of Liaocheng, Liaocheng, Shandong, China
,
Dandan Luo
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Xiaohui Su
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Dongmei Zheng
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Li Feng
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Ling Gao
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
3   Scientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China
,
Chunxiao Yu
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
,
Qingbo Guan
1   Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
› Author Affiliations
Further Information

Publication History

received 05 December 2016

accepted 27 March 2017

Publication Date:
05 July 2017 (online)

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Abstract

Obesity has increased dramatically worldwide, which is associated with male infertility. Androgen deficiency, impaired spermatogenesis, and erectile dysfunction are characteristics of male infertility. The balance of androgens and estrogens is essential for maintaining normal reproductive function in males. Aromatase, the rate-limiting enzyme in the conversion of androgens into estrogens, is present in various tissues. The expression of aromatase is proportional to body fat mass and causes more fat accumulation, thus forming a vicious cycle. Excessive aromatase activity in adipose tissue leads to increased conversion of androgens into estrogens, eventually results in a reduction of testosterone levels and is the underlying reason for obesity-related infertility. In the male reproductive system, all testicular somatic cells and germ cells express aromatase, except for peritubular myoid cells. The results of studies regarding the effect of aromatase in testicular somatic cells and germ cells have been contradictory. The effect of estrogens in testicular somatic cells is inhibitory, leading to reduced testosterone levels and sperm production; however, it has been observed that aromatase participates in the acquisition of sperm motility. The overall effect of estrogen modulation is an inhibition of spermatogenesis. Aromatase inhibitors are an effective therapy for obesity-associated hypogonadism because they restore normal sex hormone levels and improve semen parameters. This article systematically introduces the basic knowledge of aromatase and provides information of the current advances relating to aromatase in male reproductive function. Increasing our knowledge on the role of aromatase in male obesity could help in proposing new approaches to treat infertile men.

Key words

aromatase - estrogens - obesity - reproduction - testosterone
 

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