The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Maryam Akbari; Mahmood Mosazadeh; Kamran B. Lankarani; Reza Tabrizi; Mansooreh Samimi; Maryam Karamali; Mehri Jamilian; Fariba Kolahdooz; Zatollah Asemi

doi:10.1055/s-0043-115225

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2017; 49(09): 647-653
DOI: 10.1055/s-0043-115225

Review

The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Maryam Akbari

¹Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

,

Mahmood Mosazadeh

²Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

,

Kamran B. Lankarani

¹Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

,

Reza Tabrizi

¹Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

,

Mansooreh Samimi

³Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

,

Maryam Karamali

⁴Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

,

Mehri Jamilian

⁵Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran

,

Fariba Kolahdooz

⁶Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada

,

Zatollah Asemi

⁷Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

› Author Affiliations

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes (GDM) patients. We conducted an electronic systematic search of MEDLINE, and 4 other research databases from inception to August 2016, in addition to performing hand searches and consulting with experts in the field. The index of heterogeneity between studies was determined using Cochran (Q) and I-squared tests. Given the existing heterogeneity between studies, a fix or random effect model was performed to estimate the standardized mean difference (SMD) for each variable by using inverse variance method and Cohen statistics. Six randomized clinical trials (187 subjects and 184 controls) were included. The results showed that vitamin D supplementation significantly reduced the homeostasis model assessment of insulin resistance (HOMA-IR) [SMD −0.66; 95% confidence interval (CI), −1.14 to −0.18], homeostatic model assessment-B cell function (HOMA-B) (SMD −0.52; 95% CI, −0.79 to −0.25), LDL-cholesterol levels (SMD −0.33; 95% CI, −0.58 to −0.07), and significantly increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.73; 95% CI, 0.26 to 1.20). We found no beneficial effect of vitamin D supplementation on fasting plasma glucose (FPG), insulin, HbA1c, total-, HDL-cholesterol, and triglycerides concentrations. In conclusion, this meta-analysis demonstrated that vitamin D supplementation may lead to an improvement in HOMA-IR, QUICKI, and LDL-cholesterol levels, but did not affect FPG, insulin, HbA1c, triglycerides, total- and HDL-cholesterol levels; however, vitamin D supplementation increased HOMA-B.

Key words

vitamin D - glucose homeostasis - lipid profiles - meta-analysis

Full Text

References

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Supplementary Material

Supplementary Material