5,4′-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPARγ

Jing-Jie Zhu; Jun Ji; Ai-Jun Hou; He-Yao Wang

doi:10.1055/s-0043-120270

Planta Medica, Inhaltsverzeichnis

Planta Med 2018; 84(08): 500-506
DOI: 10.1055/s-0043-120270

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

5,4′-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPARγ

Jing-Jie Zhu

¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

³University of Chinese Academy of Sciences, Beijing, China

,

Jun Ji

²Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China

,

Ai-Jun Hou

²Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China

,

He-Yao Wang

¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

› Institutsangaben

Abstract

PPARγ agonists are widely used medications in diabetes mellitus therapy. Their role in improving adipose tissue function contributes to antidiabetic effects. The extracts of Dodonaea viscosa have been reported to exert antidiabetic activity. However, the effective mediators and the underlying mechanisms were largely unknown. In this study, we investigated the action on PPARγ transactivation and adipocyte modulation of two typical flavonoid constituents from D. viscosa, 5,4′-dihydroxy-7,8-dimethoxyflavanone and aliarin. Our results showed that 5,4′-dihydroxy-7,8-dimethoxyflavanone and aliarin were potential partial PPARγ agonists. The compounds induced adipogenesis in 3T3-L1 cells, with an upregulated adiponectin mRNA level and enhanced insulin sensitivity. The favorable effects of 5,4′-dihydroxy-7,8-dimethoxyflavanone, aliarin, and other flavonoid constituents on adipocytes might contribute to the antidiabetic efficacy of D. viscosa.

Key words

Dodonaea viscosa - Sapindaceae - 5,4′-dihydroxy-7,8-dimethoxyflavanone - aliarin - diabetes mellitus - adipogenesis - partial PPARγ agonists

Volltext

Referenzen

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