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Planta Med 2018; 84(08): 500-506
DOI: 10.1055/s-0043-120270
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

5,4′-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPARγ

Jing-Jie Zhu
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
3   University of Chinese Academy of Sciences, Beijing, China
,
Jun Ji
2   Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China
,
Ai-Jun Hou
2   Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China
,
He-Yao Wang
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
› Author Affiliations
Further Information

Publication History

received 21 February 2017
revised 10 September 2017

accepted 20 September 2017

Publication Date:
10 October 2017 (online)

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Abstract

PPARγ agonists are widely used medications in diabetes mellitus therapy. Their role in improving adipose tissue function contributes to antidiabetic effects. The extracts of Dodonaea viscosa have been reported to exert antidiabetic activity. However, the effective mediators and the underlying mechanisms were largely unknown. In this study, we investigated the action on PPARγ transactivation and adipocyte modulation of two typical flavonoid constituents from D. viscosa, 5,4′-dihydroxy-7,8-dimethoxyflavanone and aliarin. Our results showed that 5,4′-dihydroxy-7,8-dimethoxyflavanone and aliarin were potential partial PPARγ agonists. The compounds induced adipogenesis in 3T3-L1 cells, with an upregulated adiponectin mRNA level and enhanced insulin sensitivity. The favorable effects of 5,4′-dihydroxy-7,8-dimethoxyflavanone, aliarin, and other flavonoid constituents on adipocytes might contribute to the antidiabetic efficacy of D. viscosa.

Key words

Dodonaea viscosa - Sapindaceae - 5,4′-dihydroxy-7,8-dimethoxyflavanone - aliarin - diabetes mellitus - adipogenesis - partial PPARγ agonists
 

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