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Gesundheitswesen 2019; 81(07): e110-e120
DOI: 10.1055/s-0043-121885
Übersichtsarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Systematischer Review zur Krankheitslast durch Campylobacter spp.

Systematic Review of the Burden of Campylobacter-associated Disease
Julia Lackner
1   Exposition, Bundesinstitut fur Risikobewertung, Berlin
,
Daniela Schlichting
1   Exposition, Bundesinstitut fur Risikobewertung, Berlin
,
Christine Müller-Graf
1   Exposition, Bundesinstitut fur Risikobewertung, Berlin
,
Matthias Greiner
1   Exposition, Bundesinstitut fur Risikobewertung, Berlin
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
07. Dezember 2017 (online)

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Zusammenfassung

Campylobacter spp. sind Bakterien, die weltweit als einer der häufigsten Auslöser für eine Gastroenteritis gelten und zu schwerwiegenden Folgeerkrankungen führen können. Die Krankheitslast durch Campylobacterbakterien wurde bereits in mehreren Studien mithilfe der quantitativen Maßzahl disability-adjusted life years (DALY) für ausgewählte Länder berechnet. Ziel der Übersichtsarbeit ist es zu evaluieren, ob die berechneten DALYs in den betrachten Ländern und Zeiträume vergleichbar sind und wenn nicht, welche Faktoren die Schätzungen beeinflussen. Da als wichtigster Übertragungsweg für Campylobacter spp. Lebensmittel gelten, wurden auch Publikationen in die Suche einbezogen, die nur die lebensmittelbedingte Krankheitslast abbildeten. Mithilfe einer systematischen Literatursuche, wurden 21 länderspezifische Publikationen und eine Studie der Weltgesundheitsorganisation im Suchzeitraum 1/1996–6/2016 gefunden. Durch unterschiedliche Methoden bei der Berechnung der Krankheitslast sowie die Qualitätsunterschiede der Daten schwanken die Ergebnisse der Schätzungen der Gesamtkrankheitslast in den länderspezifischen Publikationen von 0,4 DALYs in Frankreich bis 109 DALY pro 100000 Einwohner in Polen. Da die Berechnung des attributablen Risikos auf Grundlage der mit Unsicherheiten behafteten Schätzungen der Inzidenzen der campylobacterbedingten Erkrankungen erfolgt, zeigen sich auch bei der lebensmittelbedingten Krankheitslast große Spannweiten von 0,5 DALYs pro 100000 Einwohner in Griechenland bis 21,2 DALY pro 100000 Einwohner in Neuseeland, welche nicht ausschließlich auf die länderspezifischen Variabilität in der Produktion, dem Verzehrsverhalten und dem Vorkommen von Campylobacter spp. zurückzuführen sind.

Abstract

Bacteria of the genus Campylobacter spp. are one of the most common causes of gastroenteritis and can lead to serious sequelae. Several studies have estimated the disease burden of Campylobacter spp. with the quantitative metric of disability-adjusted life years (DALY). The aim of this systematic review is to give an overview of the information available about different countries and periods for which DALYs were calculated and how the different results are comparable. One of the most important transmission pathways for Campylobacter spp. is food. Therefore, special attention was given to studies that only estimated the foodborne disease burden of Campylobacter bacteria. With a systematic search for the period 1/1996–6/2016, one worldwide and 21 country-specific publications of the WHO were identified. Because of the different methods and the quality of the different data sets, the estimated results of all Campylobacter health outcomes of the country-specific studies vary from 0.4 DALYs per 100000 people in France to 109 DALY per population in Poland. The calculation of the attributable foodborne disease burden was based on the estimations of the incidences of all Campylobacter health outcomes with the associated uncertainty for each result. So the estimations of the foodborne disease burden show a large range from 0.5 DALYs per 100000 people in Greek to 21.2 DALYs per 100000 people in New Zealand. This span can only be partially explained by the country-specific variability in the food production, the consumption behavior and the incidence of Campylobacter bacteria.

Schlüsselwörter

Krankheitslast - Campylobacter - Lebensmittelinfektionen - Übersichtsarbeit - disability-adjusted life years

Key words

Burden of Disease - Campylobacter - systematic review - disability-adjusted life years - foodborne infections
 

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