Vorsorge und Screening beim kolorektalen Karzinom^[*]

Prof. Dr. med. Jürgen F. Riemann ist einer der bedeutendsten Visionäre und Vorkämpfer der Prävention des kolorektalen Karzinoms. Das unter seiner Federführung mitentwickelte Vorsorgekonzept, unter anderem mit der Vorsorgekoloskopie ab dem 55. Lebensjahr, gilt anderen europäischen Ländern nach wie vor als Vorbild. Für den vorliegenden Widmungsbeitrag wurde daher bewusst das Thema Darmkrebsvorsorge ausgewählt.

Schlüsselwörter

Kolonkarzinom-Screening - Koloskopie - CT-Kolonografie - fäkaler Hämokkult-Test - Patientenakzeptanz

Key words

colon cancer screening - real colonoscopy - CT colonography - fecal occult blood test - patient acceptance

^* Gewidmet Herrn Prof. Dr. med. Jürgen F. Riemann anlässlich seiner Verabschiedung als DMW-Herausgeber.

• Literatur

• 1 Riemann JF. Ist Evidenz der allein entscheidende Maßstab?. Dtsch Med Wochenschr 2016; 41: 732
• 2 Ferlay J, Soerjomataram I, Dikshit R. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136: E359-E386
• 3 Andus T. Klinische Gastroenterologie: Das Buch für Fort- und Weiterbildung plus DVD mit über 1400 Befunden. Stuttgart: Thieme; 2012
• 4 Leitlinienprogramm Onkologie|S3-Leitlinie Kolorektales Karzinom. August 2014. Im Internet: http://www.awmf.org/uploads/tx_szleitlinien/021-007OLl_S3_KRK_2014-08-verlaengert.pdf
• 5 Brenner H, Altenhofen L, Katalinic A. et al. Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database. Am J Epidemiol 2011; 174: 1140-1146
• 6 Brenner H, Schrotz-King P, Holleczek B. Rückgang der Inzidenz und Mortalität von Darmkrebs in Deutschland. Dtsch Arztebl Int 2016; 113: 101-106
• 7 Song L, Li Y. Current noninvasive tests for colorectal cancer screening: An overview of colorectal cancer screening tests. World J Gastrointest Oncol 2016; 8: 793-800
• 8 van Rossum LGM, van Rijn AF. et al. Colorectal cancer screening comparing no screening, immunochemical and guaiac fecal occult blood tests: a cost-effectiveness analysis. Int J Cancer 2011; 128: 1908-1917
• 9 Lee JK, Liles EG, Bent S. et al. Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis. Ann Intern Med 2014; 160: 171
• 10 Dhaliwal A, Vlachostergios PJ, Oikonomou KG. et al. Fecal DNA testing for colorectal cancer screening: Molecular targets and perspectives. World J Gastrointest Oncol 2015; 7: 178-183
• 11 Zhu MM, Zu XT, Nie F. et al. Comparison of immunochemical and guaiac-based fecal occult blood test in screening and surveillance for advanced colorectal neoplasms: a meta-analysis. J Dig Dis 2010; 11: 148-160
• 12 Hol L, van Leeram ME, van Ballegooijen M. et al. Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy.. Gut 2010; 59: 62-68
• 13 Ladabaum U, Alvarez-Osorio L, Rösch T. et al. Cost-effectiveness of colorectal cancer screening in Germany: current endoscopic and fecal testing strategies versus plasma methylated Septin 9 DNA. Endoscopy Int Open 2014; 2: E96-E104
• 14 Hundt S, Haug U, Brenner H. Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection.. Ann Intern Med 2009; 150: 162-169
• 15 Quintero E, Castells A, Bujanda L. et al. Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening.. N Engl J Med 2012; 366: 697-706
• 16 Oort FA, van Turenhout ST, Coupé VM. et al. Double sampling of a faecal immunochemical test is not superior to single sampling for detection of colorectal neoplasia: a colonoscopy controlled prospective cohort study.. BMC Cancer 2011; 11: 434 , 2011
• 17 Health Quality Ontario. Screening methods for early detection of colorectal cancers and polyps: summary of evidence-based analyses. Ont Health Technol Assess Ser 2009; 9: 1-65
• 18 Denzer U, Beilenhoff U, Eickhoff A. et al. S2k-Leitlinie Qualitätsanforderungen in der gastrointestinalen Endoskopie (Kurzversion), AWMF-Register Nr. 021–022. Erstauflage 2015. Z Gastroenterol 2015; 53: 1496-1530
• 19 Imperiale TF, Ransohoff DF, Itzkowitz SH. et al. Multitarget stool DNA testing for colorectal-cancer screening. New Engl J Med 2014; 370: 1287-1297
• 20 Lofton-Day C, Model F, de Vos T. et al. DNA methylation biomarkers for blood-based colorectal cancer screening. Clin Chem 2008; 54: 414-423
• 21 Potter NT, Hurban P, White MN. et al. Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma. Clin Chem 2014; 60: 1183-1191
• 22 de Vos T, Tetzner R, Model F. et al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem 2009; 55: 1337-1346
• 23 Wolff WI, Shinya H. Colonofiberoscopy. JAMA 1971; 217: 1509-1512
• 24 East JE, Stavrindis M, Thomas-Gibson S. et al. A comparative study of standard vs. high definition colonoscopy for adenoma and hyperplastic polyp detection with optimized withdrawal technique. Aliment Pharmacol Ther 2008; 28: 768-776
• 25 Erim T, Rivas JM, Velis E. et al. Role of high definition colonoscopy in colorectal adenomatous polyp detection. World J Gastroenterol 2011; 17: 4001-4006
• 26 Testoni PA, Notaristefano C, Vailati C. et al. High-definition colonoscopy with i-Scan: better diagnosis for small polyps and flat adenomas. World J Gastroenterol 2012; 18: 5231-5239
• 27 Schoen RE, Pinsky PF, Weissfeld JL. et al. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. New Engl J Med 2012; 366: 2345-2357
• 28 Imperiale TF, Wagner DR, Lin CY. et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. New Engl J Med 2000; 343: 169-174
• 29 Holme Ø, Schoen RE, Senore C. et al. Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials. BMJ (Clinical research ed.) 2017; 356: i6673
• 30 Heresbach D, Djabbari M, Riou F. et al. Accuracy of computed tomographic colonography in a nationwide multicentre trial, and its relation to radiologist expertise. Gut 2011; 60: 658-665
• 31 Johnson CD, Chen M, Toledano AY. et al. Accuracy of CT colonography for detection of large adenomas and cancers. New Engl J Med 2008; 359: 1207-1217
• 32 Hartmann D, Bassler B, Schilling D. et al. Colorectal polyps: detection with dark-lumen MR colonography versus conventional colonoscopy. Radiology 2006; 238: 143-149
• 33 Franco DL, Leighton JA, Gurudu SR. Approach to Incomplete Colonoscopy: New Techniques and Technologies. Gastroenterol Hepatol 2017; 13: 476-483
• 34 Schoofs N, Devière J, van Gossum A. PillCam colon capsule endoscopy compared with colonoscopy for colorectal tumor diagnosis: a prospective pilot study. Endoscopy 2006; 38: 971-977
• 35 Eliakim R, Yassin K, Niv Y. et al. Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy. Endoscopy 2009; 41: 1026-1031
• 36 van Gossum A, Munoz-Navas M, Navas MM. et al. Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. New Engl J Med 2009; 361: 264-270
• 37 Riemann JF, Albert J, Altenhofen L. et al. Kolonkapsel als Vorsorge – Untersuchung Positionspapier der Stiftung Lebensblicke. Z Gastroenterol 2016; 54: 259