Chronische Pankreatitis und Pankreaskarzinom – Tumorrisiko und Screening

Abstract

Chronic pancreatitis is a fibroinflammatory syndrome of the exocrine pancreas, which is characterized by an increasing incidence, high morbidity and lethality. Common etiologies besides alcohol and nicotine consumption include genetic causes and risk factors. The life time risk for the development of pancreatic cancer is elevated 13- to 45-fold depending on the underlying etiology. In patients with chronic pancreatitis clinical, laboratory and imaging surveillance for early detection of complications, including pancreatic cancer, is recommended, although the available methods lack the desired sensitivity and specificity. In this article we review the epidemiology, etiologies and risk factors for chronic pancreatitis and pancreatic cancer and discuss current recommendations for screening and management of patients at risk for tumor development.

Die chronische Pankreatitis ist durch steigende Inzidenz sowie erhöhte Morbidität und Letalität gekennzeichnet: Das Lebenszeitrisiko für ein Pankreaskarzinom ist je nach Ätiologie 13- bis 45-fach erhöht. Dieser Beitrag fasst Epidemiologie, Ursachen und Risikofaktoren für chronische Pankreatitis und Pankreaskarzinom zusammen. Die aktuellen Empfehlungen zu Überwachung und Management von Patienten mit erhöhtem Tumorrisiko werden diskutiert.

Schlüsselwörter

chronische Pankreatitis - Pankreaskarzinom - Tumorscreening - Diabetes mellitus Typ 3c

Key words

chronic pancreatitis - pancreatic cancer - tumor screening - type 3c diabetes

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