Subscribe to RSS
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1055/s-0043-1761489
Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome
Funding None.![](https://www.thieme-connect.de/media/10.1055-s-00046370/202301/lookinside/thumbnails/10-1055-s-0043-1761489_2200075-1.jpg)
Abstract
This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen.
Publication History
Article published online:
30 January 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
Stuttgart · New York
-
References
- 1 Sokolov AV, Isakova-Sivak IN, Mezhenskaya DA. et al. Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific Abs with transferrin and lactoferrin to the antiviral effects of human recombinant 1. Biometals 2022; 1-26
- 2 Lucchese G, Flöel A. Molecular mimicry between SARS-CoV-2 and respiratory pacemaker neurons. Autoimmun Rev 2020; 19 (07) 102556
- 3 Kanduc D. SARS-CoV-2-induced immunosuppression: a molecular mimicry syndrome. Glob Med Genet 2022; 9 (03) 191-199
- 4 5.3.6 Cumulative analysis of post-authorization adverse event reports of Pf-07302048 (BNT162B2) received through 28-FEB-2021
- 5 Lucchese G, Vogelgesang A, Boesl F. et al. Anti-neuronal antibodies against brainstem antigens are associated with COVID-19. EBioMedicine 2022; 83: 104211
- 6 Briquez PS, Rouhani SJ, Yu J. et al. Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity. Sci Adv 2022; 8 (40) eabn3777
- 7 Vahabi M, Ghazanfari T, Sepehrnia S. Molecular mimicry, hyperactive immune system, and SARS-COV-2 are three prerequisites of the autoimmune disease triangle following COVID-19 infection. Int Immunopharmacol 2022; 112: 109183
- 8 Kanduc D. Peptide cross-reactivity: the original sin of vaccines. Front Biosci (Schol Ed) 2012; 4 (04) 1393-1401
- 9 Kanduc D. Hydrophobicity and the physico-chemical basis of immunotolerance. Pathobiology 2020; 87 (04) 268-276
- 10 Kanduc D. The role of proteomics in defining autoimmunity. Expert Rev Proteomics 2021; 18 (03) 177-184
- 11 Kanduc D. From anti-severe acute respiratory syndrome coronavirus 2 immune response to cancer onset via molecular mimicry and cross-reactivity. Glob Med Genet 2021; 8 (04) 176-182
- 12 Kanduc D. Thromboses and hemostasis disorders associated with COVID-19: the possible causal role of cross-reactivity and immunological imprinting. Glob Med Genet 2021; 8 (04) 162-170
- 13 Kanduc D. Homology, similarity, and identity in peptide epitope immunodefinition. J Pept Sci 2012; 18 (08) 487-494
- 14 Chen C, Li Z, Huang H, Suzek BE, Wu CH. UniProt Consortium. A fast peptide match service for UniProt Knowledgebase. Bioinformatics 2013; 29 (21) 2808-2809
- 15 The UniProt Consortium. UniProt: the universal protein knowledgebase. Nucleic Acids Res 2017; 45 ( D1(: D158-D169
- 16 Chen C, Huang H, Wu CH. Protein bioinformatics databases and resources. Methods Mol Biol 2017; 1558: 3-39
- 17 Guvenel A, Jozwik A, Ascough S. et al. Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection. J Clin Invest 2020; 130 (01) 523-538
- 18 Priyanka PP, Yenugu S. Coiled-coil domain-containing (CCDC) proteins: functional roles in general and male reproductive physiology. Reprod Sci 2021; 28 (10) 2725-2734
- 19 Kanduc D. The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity. Biol Chem 2019; 400 (05) 629-638