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CC BY 4.0 · Indian Journal of Neurosurgery 2023; 12(02): 155-162
DOI: 10.1055/s-0043-1761604
Original Article

Brain Tumor Vascularity Estimation by Arterial Spin Label Perfusion MRI—A Preoperative Tool for Patient Prognostication

Nidhi Rai
1   Department of Radiodiagnosis, VMMC and Safdarjung Hospital, New Delhi, India
,
Rupi Jamwal
1   Department of Radiodiagnosis, VMMC and Safdarjung Hospital, New Delhi, India
,
Bhanu Pratap Singh
2   Department of Neurosurgery, GB Pant Hospital, New Delhi, India
,
Jyoti Gupta 
1   Department of Radiodiagnosis, VMMC and Safdarjung Hospital, New Delhi, India
,
K. B. Shankar
3   Department of Neurosurgery, VMMC and Safdarjung Hospital, New Delhi, India
,
Sufiyan Zaheer
4   Department of Pathology, VMMC and Safdarjung Hospital, New Delhi, India
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Abstract

Introduction Brain tumors remain a significant cause of morbidity and mortality around the globe. Preoperative estimation of tumor vascularity is of great significance for a neurosurgeon. Aim of our study was to correlate tumor blood flow (TBF) using arterial spin labeling perfusion imaging (ASL-PI) with microvessel density (MVD), tumor grade, and preoperative prognostication of brain tumors.

Materials and Methods This was a prospective observational cross-sectional study conducted in 63 patients of primary brain tumors already referred for magnetic resonance imaging. Absolute and relative mean and maximum TBF were calculated using ASL-PI and correlated with tumor grade and MVD at 10x and 40x magnificantion; thereby stydying the role of ASL-PI in brain tumor prognostication.

Results The mean of maxTBF values (mL/min/100 g) in the gliomas group, meningiomas group, schwannoma group, craniopharyngioma group, and hemangioblastoma group was 147.15, 251.55, 96.43, 43.3, and 578.3, respectively. The median of maxTBF value in the gliomas group, meningiomas group, schwannoma group, craniopharyngioma group, and hemangioblastoma group was 131.5, 158.63, 94.5, 43.4, and 578.3, respectively.

Discussion Significant correlation between meanTBF and MVD at 10X magnification (p-value < 0.001, rho =0.88) and a positive correlation between meanTBF and MVD at 40X magnification (p-value < 0.001) were seen. Significant correlation was also seen between maxTBF and MVD at 10X magnification (p-value < 0.001, rho = 0.91) and between maxTBF and MVD at 40X magnification. TBF in case of the hemangioblastoma was higher than other types of brain tumors (gliomas, meningiomas, and schwannomas). HighTBF value was seen in high-grade gliomas compared with low-grade gliomas with worse prognosis. TBF was high in typical meningiomas whereas low in atypical meningioma.

Conclusion TBF by ASL-PI can be considered a noninvasive in vivo marker in predicting the grade of brain tumors and further assist in envisaging prognosis of the patients with brain tumors.

Keywords

Arterial spin labelled perfusion imaging (ASL-PI) - brain tumors - preoperative prognostication - tumor blood flow (TBF) estimation - tumor microvessel density

Authors' Contribution

J.G. and R.J. contributed in conceptualization, reviewing, and editing of draft. N.R. collected data and formulated initial draft. B.P.S. provided surgical details and reviewed the draft. K.B.S. provided surgical details. S.Z. performed histopathological analysis.




Publikationsverlauf

Artikel online veröffentlicht:
14. April 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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