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DOI: 10.1055/s-0043-1762939
Lenvatinib Can Overcome Immune Resistance in Head and Neck Cancer and Achieve Durable Remission
Authors
Squamous cell carcinoma head and neck is the sixth most common cancer worldwide and.[1] Multimodality therapies have been advocated for locoregional relapse or metastatic disease.[2] Combination therapy with lenvatinib has been considered to overcome resistance and improve the efficacy.[3] In a recent study of lenvatinib and pembrolizumab conducted in heavily pretreated recurrent and metastatic head and neck cancer, the median overall survival OS was 6.2 months, and the median progression-free survival (PFS) was 4.6 months.[4]
This combination is currently undergoing study in LEAP-010.[5] Herein, we report a case of heavily pretreated metastatic head and neck cancer in a patient who was treated with a combination of lenvatinib with pembrolizumab.
Publication History
Article published online:
09 March 2023
© 2023. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
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- 2 Karabajakian A, Toussaint P, Neidhardt EM, Paulus V, Saintigny P, Fayette J. Chemotherapy for recurrent/metastatic head and neck cancers. Anticancer Drugs 2017; 28 (04) 357-361
- 3 Morrissey KM, Yuraszeck TM, Li CC, Zhang Y, Kasichayanula S. Immunotherapy and novel combinations in oncology: current landscape, challenges and opportunities. Clin Transl Sci 2016; 9 (02) 89-104
- 4 Chen T-H, Chang PM, Yang MH. Combination of pembrolizumab and lenvatinib is a potential treatment option for heavily pretreated recurrent and metastatic head and neck cancer. J Chin Med Assoc 2021; 84 (04) 361-367
- 5 Merck Sharp & Dohme Corp. . 2022. A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010) (LEAP-10) (Clinical Trial Registration No. NCT04199104). clinicaltrials.gov. Accessed January 25, 2023. https://clinicaltrials.gov/ct2/show/NCT04199104