Synthesis, Inhaltsverzeichnis Synthesis 2024; 56(11): 1702-1710DOI: 10.1055/s-0043-1763660 paper New Trends in Organic Synthesis from Chinese Chemists Photoredox-Catalyzed C(sp3)–H Difluoroallylation of Amides Yanmei Lin , Xiaomin Shu , Haohua Huo ∗ Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract A photoredox-catalyzed, bromine-radical-mediated C(sp3)–H difluoroallylation of amides is disclosed. This modular approach exploits the hydrogen atom transfer (HAT) ability of photooxidatively generated bromine radicals to convert both cyclic and acyclic amides into the corresponding α-amino alkyl radicals that then are coupled with readily available trifluoromethyl alkenes. This method is distinguished by its mild conditions, broad substrate scope (30 examples), and the use of a simple HAT reagent, namely sodium bromide (NaBr). This strategy offers a promising paradigm for the incorporation of carbonyl isosteres into saturated aliphatic amines. 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