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Synthesis 2024; 56(13): 2093-2099
DOI: 10.1055/s-0043-1763758
DOI: 10.1055/s-0043-1763758
paper
Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one
This research was financed by the French Government IDEX-ISITE Initiative 16-IDEX-0001 (CAP 20-25), Université Clermont-Auvergne, Institut National de la Santé et de la Recherche Médicale (Inserm), Centre National de la Recherche Scientifique (CNRS), and the Région Auvergne-Rhône-Alpes (Pack Ambition Recherche). The authors also thank WeylChem InnoTec (Frankfurt, Germany) for financial support.
Abstract
An optimization of the synthesis of 3,5-disubstituted pyridin-2(1H)-ones with in vivo anti-allodynic activity was conducted. The optimized synthesis was employed to prepare novel analogues which were then assessed for their efficacy in preventing cutaneous mechanical allodynia in a male rat hindpaw capsaicin model.
Key words
pyridin-2(1H)-ones - synthesis optimization - palladium catalysis - mechanical allodynia - analgesicsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1763758.
- Supporting Information
Publication History
Received: 17 April 2024
Accepted after revision: 02 May 2024
Article published online:
22 May 2024
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