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CC BY-NC-ND 4.0 · South Asian J Cancer 2024; 13(02): 106-109
DOI: 10.1055/s-0043-1764123
Original Article
Head and Neck Cancer

Lymphocytic Host Response and other Prognostic Factors in Early Stage Squamous Cell Carcinoma of Tongue: Retrospective Analysis from a Tertiary Cancer Center

Aswin Anapathoor Nagarajan
1   Department of Radiation Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India
,
Swaminathan Rajaraman
2   Department of Epidemiology, Biostatistics and Cancer Registry, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India
,
Shirley Sundersingh
3   Department of Pathology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India
,
Rajkumar Thangarajan
4   Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India
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Abstract

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Aswin Anapathoor Nagarajan

Introduction The tongue is the most common site of malignancy in the oral cavity, and squamous cell carcinoma is the commonest histology. The prognosis remains unfavorable despite treatment, resulting in higher mortality rates. Early stage carcinoma of the tongue is a distinct entity and is primarily treated with either surgery or radiotherapy. Various factors have been implicated in the prognosis of early stage tongue carcinomas. The main objective of this study is to access whether the lymphocytic host response (LHR) and other prognostic factors influence the survival.

Patients and Methods The data of 129 patients with Stage I and Stage II (T1-2, N0) tongue cancer treated in our institute from January 2012 to December 2016 were retrospectively abstracted from the hospital case records. The various clinical and pathological factors were recorded. The Kaplan–Meier model was used for survival analysis. The disease-free survival (DFS) and the overall survival (OS) with respect to stage and LHR were calculated.

Results On multivariate analysis, site of lesion, comorbidities, habits, grade of the tumor, perineural infiltration (PNI) did not influence the survival. The main factor which was found to be significant in DFS was LHR. The DFS was better for the patients who had lymphocytic infiltration of ≥ 70% (strong LHR) when compared with <70%(weak LHR) (p = 0.037). The OS with respect to stage (p = 0.608) and LHR (p = 0.164) was not found to be statistically significant.

Conclusion The patients with weak LHR had less DFS when compared with patients with strong LHR. Larger studies are needed to evaluate whether adding adjuvant therapy may benefit the patients with weak LHR in early stage tongue cancer.

Keywords

squamous cell carcinoma - lymphocytic host response - Kaplan–Meier model - disease-free survival (DFS) - overall survival (OS)


Publication History

Article published online:
09 June 2023

© 2023. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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