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CC BY-NC-ND 4.0 · South Asian J Cancer 2023; 12(02): 213-216
DOI: 10.1055/s-0043-1764148
Original Article

Ewing Sarcoma with Ganglion Cells Post-Chemotherapy: A Case Report with Review of Literature

Karthik Dhandapani 
1   Department of Onco-pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
,
Jahnavi Gandhi 
1   Department of Onco-pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
,
Amisha Gami 
1   Department of Onco-pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
› Author Affiliations Funding None.
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Abstract

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Karthik Dhandapani

Ewing sarcoma arises in both bones (most common) and soft tissues and it commonly affects young adults. The tumor is composed of small round cells showing positivity for CD99 and FLI1 on immunohistochemistry (IHC). We describe ganglion cell differentiation post-chemotherapy in Ewing sarcoma which is a rare phenomenon.

A 13-year-old girl presented with a chest wall mass. On biopsy correlating with IHC, the diagnosis was rendered as Ewing sarcoma. She underwent neoadjuvant chemotherapy followed by resection of the tumor. On microscopic evaluation, the tumor showed prominent ganglionic differentiation with expression of neuronal markers.

Although maturation post-chemotherapy is an established finding with better prognosis in other primitive pediatric tumors, such neural differentiation is rare with only a few case reports in Ewing sarcoma both post- and pre-chemotherapy. Clinical significance and prognosis of such differentiation which appear to be better are not yet established and needs to be elucidated.

Keywords

Ewing sarcoma - ganglion cell - neural differentiation - chemotherapy - maturation


Publication History

Article published online:
01 March 2023

© 2023. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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