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CC BY 4.0 · Pharmaceutical Fronts 2023; 05(01): e25-e30
DOI: 10.1055/s-0043-1764226
Original Article

Study on the Synthesis of Dihydroflavonol Compounds

Zhi-Teng Du
1   Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, People's Republic of China
,
Zeng Zhao
2   State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Qing-Yan Sun
2   State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Wei-Dong Zhang
1   Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, People's Republic of China
2   State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
› Author Affiliations Funding This work was supported by Three-year Action Plan for Shanghai TCM Development and Inheritance Program (Grant No. ZY [2021-2023]-0401) and Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (Grant No. ZYYCXTD-D-202004).
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Abstract

From the roots of Campylotropis hirtella (Franch.) Schindl., many natural dihydroflavonol compounds have been extracted, and they possess a structurally novel feature of chiral tertiary alcohol groups. However, the content of the compounds in the plant is extremely low. At this point, to satisfy the needs of further experimental research on these compounds, much effort has been invested in the chemical synthesis of the core structure of 3-hydroxy-3-phenylchroman-4-one. This study aimed to explore a novel method for the synthesis of dihydroflavonol (3), and its application in the production of a natural product (14). The method started with commercially available materials, and provided a foundation for total synthesis of natural compounds of dihydroflavonol.

Keywords

natural compounds - dihydroflavonol - synthesis

Supplementary Material



Publication History

Received: 19 December 2022

Accepted: 30 January 2023

Article published online:
09 March 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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