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DOI: 10.1055/s-0043-1767802
Economic Burden of Otitis Media Globally and an Overview of the Current Scenario to Alleviate the Disease Burden: A Systematic Review
Funding Indian Council of Medical Research. 5/7/1668/CH/CAR/2019-RBMCH date - 3/01/2019.Abstract
Introduction The prevalence of otitis media (OM) is substantial all over the world. Epidemiological data related to the economic burden of OM globally is minimal. The present systematic review was undertaken to estimate the economic burden of this disease in various parts of the world.
Objectives An extensive literature search was done using PRISMA guidelines to identify relevant studies that estimated the economic burden of OM in monetary terms. The databases searched were PubMed Central, Ovid, and Embase. The cost estimation was done for one specific year and then compared considering the inflation rate.
Data Synthesis The literature search led to the inclusion of 10 studies. The studies evaluated direct and indirect costs in monetary terms. Direct costs (health system and patient perspective) ranged from USD (United States Dollar) 122.64 (Netherlands) to USD 633.6 (USA) per episode of OM. Looking at only the patient perspective, the costs ranged from USD 19.32 (Oman) to USD 80.5 (Saudi Arabia). The total costs (direct and indirect) ranged from USD 232.7 to USD 977 (UK) per episode of OM. The economic burden per year was highest in the USA (USD 5 billion). The incidence of OM episodes was found more in children < 5 years old. Introduction of pneumococcal conjugate vaccines decreased the incidence in children and now the prevalence in adults is of concern.
Conclusion The economic burden of OM is relatively high globally and addressing this public health burden is important. Approaches for the prevention, diagnosis, and treatment should be undertaken by the health system to alleviate this disease burden.
Publikationsverlauf
Eingereicht: 17. Oktober 2022
Angenommen: 20. Februar 2023
Artikel online veröffentlicht:
05. Juli 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Ibekwe TS, Nwaorgu OG. Classification and management challenges of otitis media in a resource-poor country. Niger J Clin Pract 2011; 14 (03) 262-269
- 2 Monasta L, Ronfani L, Marchetti F. et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One 2012; 7 (04) e36226
- 3 Kohli C, Kadirvelu U, Garg S, Sharma N. Burden of ear morbidities among children in primary care setting in Delhi. Clin Epidemiol Glob Health 2016; 4: S12-S16
- 4 Meherali S, Campbell A, Hartling L, Scott S. Understanding Parents' Experiences and Information Needs on Pediatric Acute Otitis Media: A Qualitative Study. J Patient Exp 2019; 6 (01) 53-61
- 5 Hafidh MA, Keogh I, Walsh RM, Walsh M, Rawluk D. Otogenic intracranial complications. a 7-year retrospective review. Am J Otolaryngol 2006; 27 (06) 390-395
- 6 Fireman P. Otitis media and eustachian tube dysfunction: connection to allergic rhinitis. J Allergy Clin Immunol 1997; 99 (02) S787-S797
- 7 Siddiq S, Grainger J. The diagnosis and management of acute otitis media: American Academy of Pediatrics Guidelines 2013. Arch Dis Child Educ Pract Ed 2015; 100 (04) 193-197
- 8 Cohen SB. Sample Design of the 1996 Medical Expenditure Panel Survey Medical Provider Component. J Econ Soc Meas 1998; 24 (01) 25-53
- 9 Lieberthal AS, Carroll AE, Chonmaitree T. et al. The diagnosis and management of acute otitis media. Pediatrics 2013; 131 (03) e964-e999
- 10 Wolleswinkel-van den Bosch JH, Stolk EA, Francois M, Gasparini R, Brosa M. The health care burden and societal impact of acute otitis media in seven European countries: results of an Internet survey. Vaccine 2010; 28 (Suppl 6): G39-G52
- 11 Zhang XH, Nievera MC, Carlos J. et al. Cost-Effectiveness Analysis of Pneumococcal Vaccination with the Pneumococcal Polysaccharide NTHi Protein D Conjugate Vaccine in the Philippines. Value Health Reg Issues 2014; 3: 156-166
- 12 Kim YE, Lee YR, Park SY, Lee KS, Oh IH. The Economic Burden of Otitis Media in Korea, 2012: A Nationally Representative Cross-Sectional Study. BioMed Res Int 2016; 2016: 3596261
- 13 Lenz-Alcayaga R. Análisis de costos en evaluaciones económicas en salud: Aspectos introductorios. Rev Med Chil 2010; 138: 88-92
- 14 Bukurov B, Arsovic N, Grujicic SS, Haggard M, Spencer H, Marinkovic JE. Psychometric characteristics of the chronic Otitis media questionnaire 12 (COMQ - 12): stability of factor structure and replicability shown by the Serbian version. Health Qual Life Outcomes 2017; 15 (01) 207
- 15 Phillips CJ. . Health economics: an introduction for health professionals: John Wiley & Sons; 2008
- 16 Coronell-Rodríguez W, Arteta-Acosta C, Alvis-Zakzuk N, Alvis-Guzmán N. Costs of acute otitis media in children in a city of the Colombian Caribbean coast. Biomédica 2019; 39 (01) 75-87
- 17 Boruk M, Lee P, Faynzilbert Y, Rosenfeld RM. Caregiver well-being and child quality of life. Otolaryngol Head Neck Surg 2007; 136 (02) 159-168
- 18 Homøe P, Heidemann CH, Damoiseaux RA. et al. Panel 5: Impact of otitis media on quality of life and development. Int J Pediatr Otorhinolaryngol 2020; 130 (Suppl 1, Suppl 1) 109837
- 19 Chando S, Young C, Craig JC, Gunasekera H, Tong A. Parental views on otitis media: systematic review of qualitative studies. Eur J Pediatr 2016; 175 (10) 1295-1305
- 20 Litra A. The inflation rate determined as a change in the GDP deflator and in CPI. Bulletin of the Transilvania University of Brasov: Economic Sciences Series V 2009; 2: 207- -212
- 21 Kochhar S, Rath B, Seeber LD, Rundblad G, Khamesipour A, Ali M. Vienna Vaccine Safety Initiative. Introducing new vaccines in developing countries. Expert Rev Vaccines 2013; 12 (12) 1465-1478
- 22 Türel O, Kisa A, McIntosh ED, Bakir M. Potential cost-effectiveness of pneumococcal conjugate vaccine (PCV) in Turkey. Value Health 2013; 16 (05) 755-759
- 23 Pneumococcal conjugate vaccine for childhood immunization--WHO position paper. Releve epidemiologique Hebdomadaire 2007; 82 (12) 93-104 PubMed
- 24 Pichichero M, Kaur R, Scott DA. et al. Effectiveness of 13-valent pneumococcal conjugate vaccination for protection against acute otitis media caused by Streptococcus pneumoniae in healthy young children: a prospective observational study. Lancet Child Adolesc Health 2018; 2 (08) 561-568
- 25 Mustafa G, Al Aidaroos AY, Al Abaidani IS. et al. Incidence and economic burden of acute otitis media in children aged up to 5years in three Middle Eastern countries and Pakistan: A multinational, retrospective, observational study. J Epidemiol Glob Health 2017; 7 (02) 123-130
- 26 Marom T, Tan A, Wilkinson GS, Pierson KS, Freeman JL, Chonmaitree T. Trends in otitis media-related health care use in the United States, 2001-2011. JAMA Pediatr 2014; 168 (01) 68-75
- 27 Tong S, Amand C, Kieffer A, Kyaw MH. Trends in healthcare utilization and costs associated with acute otitis media in the United States during 2008-2014. BMC Health Serv Res 2018; 18 (01) 318
- 28 Wang XJ, Saha A, Zhang XH. Cost-effectiveness analysis of a universal mass vaccination program with a PHiD-CV 2+1 schedule in Malaysia. Cost Eff Resour Alloc 2017; 15: 17
- 29 Zhang XH, Leeuwenkamp O, Oh KB, Lee YE, Kim CM. Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea. Hum Vaccin Immunother 2018; 14 (01) 85-94
- 30 Speets AM, Wolleswinkel JH, Forsgren A, Sobocki PA. Use of medical resources and indirect costs of otitis media in Sweden. Scand J Public Health 2011; 39 (02) 137-146
- 31 World Health Organization. . The Global Health Observatory. Disability-Adjusted Life Years.[Internet][cited on 25 Dec 2022].Available from https://www.who.int/data/gho/indicator-metadata-registry/imr-details/158
- 32 Oh PI, Maerov P, Pritchard D, Knowles SR, Einarson TR, Shear NH. A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children. Clin Ther 1996; 18 (01) 160-182
- 33 Prieto L, Sacristán JA. Problems and solutions in calculating quality-adjusted life years (QALYs). Health Qual Life Outcomes 2003; 1: 80
- 34 Sun D, McCarthy TJ, Liberman DB. Cost-Effectiveness of Watchful Waiting in Acute Otitis Media. Pediatrics 2017; 139 (04) e20163086
- 35 Smolinski NE, Antonelli PJ, Winterstein AG. Watchful Waiting for Acute Otitis Media. Pediatrics 2022; 150 (01) e2021055613
- 36 Ahmed S, Shapiro NL, Bhattacharyya N. Incremental health care utilization and costs for acute otitis media in children. Laryngoscope 2014; 124 (01) 301-305
- 37 Dinleyici EC, Yuksel F, Yargic ZA, Unalacak M, Unluoglu I. Results of a national study on the awareness of and attitudes toward acute otitis media (AOM) among clinicians and the estimated direct healthcare costs in Turkey (TR-AOM Study). Int J Pediatr Otorhinolaryngol 2013; 77 (05) 756-761
- 38 van Uum RT, Venekamp RP, Pasmans CTB. et al. Cost of childhood acute otitis media in primary care in the Netherlands: economic analysis alongside a cluster randomised controlled trial. BMC Health Serv Res 2021; 21 (01) 193
- 39 Crawford B, Hashim SS, Prepageran N. et al. Impact of Pediatric Acute Otitis Media on Child and Parental Quality of Life and Associated Productivity Loss in Malaysia: A Prospective Observational Study. Drugs Real World Outcomes 2017; 4 (01) 21-31