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CC BY 4.0 · Arq Neuropsiquiatr 2023; 81(04): 334-339
DOI: 10.1055/s-0043-1768157
Original Article

Analysis of risk factors associated with cerebral angiography headache

Análise de fatores de risco associados a cefaleia da angiografia cerebral
Tiago Madeira 
1   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
2   Hospital Santa Rita de Cássia, Departamento de Neurologia e Neurocirurgia, Vitória ES, Brazil.
,
Amanda Viguini Tolentino Correa 
2   Hospital Santa Rita de Cássia, Departamento de Neurologia e Neurocirurgia, Vitória ES, Brazil.
,
Gabriela de Paula Abranches 
2   Hospital Santa Rita de Cássia, Departamento de Neurologia e Neurocirurgia, Vitória ES, Brazil.
,
Marcelo Rodrigues Masruha 
1   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
› Author Affiliations Support The present study was financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES, in the Portuguese acronym) – Finance Code 001.
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Abstract

Background Despite previous studies indicating a moderate/high incidence of angiography headache (AH), there is still limited data about the risk factors associated with its occurrence.

Objective The present study aimed to assess the associations among demographic, clinical, and technical characteristics of cerebral digital subtraction angiography (DSA) and the occurrence of AH.

Methods Cross-sectional analytical observational study with a sample comprised of individuals with a recommendation for elective DSA. Clinical interviews were conducted to assess the occurrence of AH, using a standardized questionnaire.

Results Among 114 subjects, the mean age was 52.8 (±13.8) years old, 75.4% (86/114) were women, 29.8% (34/114) had a history of migraines, and 10.5% (12/114) had chronic headaches. The overall frequency of AH was 45.6% (52/114). Of those, 88.4% (46/52) underwent 3D angiography, 7.7% (4/52) underwent aortography, and 1.9% (1/52) underwent both procedures. There was a statistically significant association between AH and previous history of migraine (odds ratio [OR]: 4.9; 95% confidence interval [CI] 1.62–14.7; p = 0.005) and 3D angiography (OR 6.62; 95%CI: 2.04–21.5; p = 0.002).

Conclusions 3D angiography is strongly associated with the occurrence of AH, which has never been reported before. The association between a previous history of migraine and AH confirms the results of previous studies.

Resumo

Antecedentes Apesar de estudos prévios indicarem uma incidência moderada/alta de cefaleia da angiografia (CA), os dados sobre os fatores de risco associados à sua ocorrência ainda são relativamente escassos.

Objetivo O presente estudo teve como objetivo avaliar as associações entre as características demográficas, clínicas e técnicas da angiografia cerebral por subtração digital (ACSD) e a ocorrência de CA.

Métodos Estudo observacional analítico transversal com uma amostra composta por indivíduos com indicação de ACSD em caráter eletivo. Entrevistas clínicas foram realizadas utilizando um questionário padronizado para acessar a ocorrência de CA.

Resultados Entre os 114 indivíduos, a idade média foi de 52,8 (±13,8) anos, 75,4% (86/114) eram mulheres, 29,8% (34/114) tinham histórico de enxaqueca e 10,5% (12/114) tinham cefaleia crônica. A frequência geral de CA foi de 45,6% (52/114). Desses, 88,4% (46/52) foram submetidos à angiografia 3D, 7,7% (4/52), à aortografia e 1,9% (1/52), aos dois procedimentos. Houve associação estatisticamente significativa entre CA e histórico prévio de enxaqueca (odds ratio [OR] 4,9; intervalo de confiança [IC] 95%: 1,62–14,7; p = 0,005) e angiografia 3D (OR 6,62; IC95%: 2,04–21,5; p = 0,002).

Conclusões A angiografia 3D está fortemente associada à ocorrência de CA, o que é inédito na literatura. A associação entre um histórico de enxaqueca e a CA confirma os resultados de estudos anteriores.

Keywords

Cerebral Angiography - Headache - Migraine Disorders - Headache Disorders, Secondary - Headache Disorders

Palavras-chave

Angiografia Cerebral - Cefaleia - Transtornos de Enxaqueca - Cefaleias Secundárias - Transtornos da Cefaleia

Authors' Contributions

TM: data curation, funding acquisition, investigation, methodology, writing – original draft, writing – review & editing; AVTC, GPA: writing – review & editing; MMR: conceptualization, data curation, project administration, writing – original draft, writing – review & editing.




Publication History

Received: 18 October 2022

Accepted: 18 January 2023

Article published online:
09 May 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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