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CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(02): 194-198
DOI: 10.1055/s-0043-1768181
Case Report with Review of Literature

Tamoxifen-Induced Cutaneous Vasculitis—A Rare Case Report with Review of Literature

Ankita Das
1   Department of Surgical Oncology, Breast Services, Tata Memorial Center, India
,
Ayushi Sahay
2   Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Shalaka Joshi
1   Department of Surgical Oncology, Breast Services, Tata Memorial Center, India
› Institutsangaben
Funding None declared.
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Abstract

Tamoxifen is a selective estrogen receptor modulator and forms the mainstay of endocrine therapy in premenopausal women with breast cancer in both adjuvant and metastatic setting. Common adverse effects are menopausal symptoms with venous thrombosis and endometrial carcinoma being rarer but more sinister complications. Vasculitis is a rarely reported reaction to tamoxifen. We report a case of a 38-year-old woman with locally advanced breast cancer, who received neoadjuvant chemotherapy followed by modified radical mastectomy and adjuvant paclitaxel. She was on maintenance tamoxifen and leuprolide for 3 months, when she presented with pruritic bilateral maculopapular rash over all her limbs, legs more than hands. A skin biopsy from the left lower limb confirmed the diagnosis of vasculitis. Tamoxifen was stopped, and patient was switched to letrozole and leuprolide. She was given antihistamines, antibiotics, fusidic acid, vitamin C, and topical steroids. The lesions resolved completely in 1 month after stoppage of tamoxifen. We report this rare side effect of tamoxifen so that oncologists can effectively diagnose and treat this distressing but reversible condition.

Keywords

tamoxifen-induced vasculitis - breast cancer - endocrine therapy - side effects of tamoxifen

Authors' Contributions

S.J. contributed to conceptualization, designing, definition of intellectual content, manuscript editing, and manuscript review. A.D. helped in literature search, clinical studies, data acquisition, and manuscript preparation.


Patient Consent

Patients consent was taken for use her clinical images and data for publication.




Publikationsverlauf

Artikel online veröffentlicht:
08. Mai 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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