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CC BY 4.0 · World J Nucl Med 2023; 22(02): 124-129
DOI: 10.1055/s-0043-1768446
Original Article

Impact of Region-of-Interest Delineation on Stability and Reproducibility of Liver SNR Measurements in 68Ga-PSMA PET/CT

Authors

  • Masoomeh Fooladi

    1   Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran

  • Sahar Rezaei

    2   Department of Radiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    3   Clinical Research Development Unit, Imam Reza General Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

  • Farahnaz Aghahosseini

    4   Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

  • Yalda Salehi

    4   Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

  • Nima Kasraie 

    5   Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, United States

  • Peyman Sheikhzadeh 

    1   Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
    4   Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Funding This work was supported under grant number 55707, Tehran University of Medical Sciences.
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Abstract

Objective This study aims to assess the impact of various regions of interest (ROIs) and volumes of interest (VOIs) delineations on the reproducibility of liver signal-to-noise-ratio (SNRliver) measurements, as well as to find the most reproducible way to estimate it in gallium-68 positron emission tomography (68Ga-PET) imaging. We also investigated the SNRliver-weight relationship for these ROIs and VOIs delineations.

Methods A cohort of 40 patients (40 males; mean weight: 76.5 kg [58–115 kg]) with prostate cancer were included. 68Ga-PET/CT imaging (mean injected activity: 91.4 MBq [51.2 MBq to 134.1 MBq] was performed on a 5-ring bismuth germanium oxide-based Discovery IQ PET/CT using ordered subset expectation maximization image reconstruction algorithm. Afterward, circular ROIs and spherical VOIs with two different diameters of 30 and 40 mm were drawn on the right lobe of the livers. The performance of the various defined regions was evaluated by the average standardized uptake value (SUVmean), standard deviation (SD) of the SUV (SUVSD), SNRliver, and SD of the SNRliver metrics.

Results There were no significant differences in SUVmean among the various ROIs and VOIs (p > 0.05). On the other hand, the lower SUVSD was obtained by spherical VOI with diameter of 30 mm. The largest SNRliver was obtained by ROI (30 mm). The SD of SNRliver with ROI (30 mm) was also the largest, while the lowest SD of SNRliver was observed for VOI (40 mm). There is a higher correlation coefficient between the patient-dependent parameter of weight and the image quality parameter of SNRliver for both VOI (30 mm) and VOI (40 mm) compared to the ROIs.

Conclusion Our results indicate that SNRliver measurements are affected by the size and shape of the respective ROIs and VOIs. The spherical VOI with a 40 mm diameter leads to more stable and reproducible SNR measurement in the liver.

Keywords

68Ga-PET - quality control - image quality - signal-to-noise ratio - region of interest


Publication History

Article published online:
16 May 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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