Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

Shyer Wern Goh; Wen Hon Darren Wee; Wen Xin Rachel Chua; Bingwen Eugene Fan

doi:10.1055/s-0043-1768937

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2024; 50(01): 119-129
DOI: 10.1055/s-0043-1768937

Letter to the Editor

Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

Shyer Wern Goh

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

,

Wen Hon Darren Wee

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

,

Wen Xin Rachel Chua

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

,

Bingwen Eugene Fan

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

²Department of Haematology, Tan Tock Seng Hospital, Singapore, Singapore

³Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore

⁴Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

› Author Affiliations

Abstract

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References

References
1 Alsermani M, Alzahrani H, El Fakih R. Hematidrosis: a fascinating phenomenon-case study and overview of the literature. Semin Thromb Hemost 2018; 44 (03) 293-295
2 Kluger N. Hematidrosis (bloody sweat): a review of the recent literature (1996-2016). Acta Dermatovenerol Alp Panonica Adriat 2018; 27 (02) 85-90
3 Duffin J. Sweating blood: history and review. CMAJ 2017; 189 (42) E1315-E1317
4 Holoubek JE, Holoubek AB. Blood, sweat and fear. “A classification of hematidrosis”. J Med 1996; 27 (3-4): 115-133
5 Carrion-Alvarez D, Trejo-Castro AI, Salas-Garza M, Fajardo-Ramirez OR, Salas-Alanis JC. Hematohidrosis, hemolacria, and “trichorrhage”: a systematic review. Skin Appendage Disord 2022; 8 (03) 179-185
6 Favaloro EJ, Lippi G. Commentary: controversies in thrombosis and hemostasis Part 1 - Hematidrosis: “Blood, sweat and fears” or a “pigment of fertile imaginations?”. Semin Thromb Hemost 2018; 44 (03) 296-297
7 Carvalho AC, Machado-Pinto J, Nogueira GC, Almeida LM, Nunes MB. Hematidrosis: a case report and review of the literature. Int J Dermatol 2008; 47 (10) 1058-1059
8 Bhagwat PV, Tophakhane RS, Rathod RM, Shashikumar BM, Naidu V. Hematohidrosis. Indian J Dermatol Venereol Leprol 2009; 75 (03) 317-318
9 Jerajani HR, Jaju B, Phiske MM, Lade N. Hematohidrosis - a rare clinical phenomenon. Indian J Dermatol 2009; 54 (03) 290-292
10 Kennedy WR, Wendelschafer-Crabb G, Brelje TC. Innervation and vasculature of human sweat glands: an immunohistochemistry-laser scanning confocal fluorescence microscopy study. J Neurosci 1994; 14 (11, Pt 2): 6825-6833
11 Zugibe FT. The Crucifixion of Jesus, Completely Revised and Expanded: A Forensic Inquiry. 2nd ed. M. Evans& Co Inc; 2005: 11-15
12 López García de Lomana A, Vilhjálmsson AI, McGarrity S. et al. Metabolic response in endothelial cells to catecholamine stimulation associated with increased vascular permeability. Int J Mol Sci 2022; 23 (06) 3162
13 Manonukul J, Wisuthsarewong W, Chantorn R, Vongirad A, Omeapinyan P. Hematidrosis: a pathologic process or stigmata. A case report with comprehensive histopathologic and immunoperoxidase studies. Am J Dermatopathol 2008; 30 (02) 135-139
14 Scott CT. A case of haematidrosis. BMJ 1918; 1 (2993): 532-533
15 Mishra KL. Bloody tears and hematohidrosis in a patient of PF3 dysfunction: a case report. Cases J 2009; 2: 9029
16 Patel RM, Mahajan S. Hematohidrosis: a rare clinical entity. Indian Dermatol Online J 2010; 1 (01) 30-32
17 Wang Z, Yu Z, Su J. et al. A case of hematidrosis successfully treated with propranolol. Am J Clin Dermatol 2010; 11 (06) 440-443
18 Praveen BK, Vincent J. Hematidrosis and hemolacria: a case report. Indian J Pediatr 2012; 79 (01) 109-111
19 Mora E, Lucas J. Hematidrosis: blood sweat. Blood 2013; 121 (09) 1493
20 Khalid SR, Maqbool S, Raza N, Mukhtar T, Ikram A, Qureshi S. Ghost spell or hematohidrosis. J Coll Physicians Surg Pak 2013; 23 (04) 293-294
21 Bhattacharya S, Das MK, Sarkar S, De A. Hematidrosis. Indian Pediatr 2013; 50 (07) 703-704
22 Biswas S, Surana T, De A, Nag F. A curious case of sweating blood. Indian J Dermatol 2013; 58 (06) 478-480
23 Deshpande M, Indla V, Kumar V, Reddy IR. Child who presented with hematohidrosis (sweating blood) with oppositional defiant disorder. Indian J Psychiatry 2014; 56 (03) 289-291
24 Shen H, Wang Z, Wu T. et al. Haematidrosis associated with epilepsy in a girl successfully treated with oxcarbazepine: case report. J Int Med Res 2015; 43 (02) 263-269
25 Uber M, Robl R, Abagge KT. et al. Hematohidrosis: insights in the pathophysiology. Int J Dermatol 2015; 54 (12) e542-e543
26 Jafar A, Ahmad A. Child who presented with facial hematohidrosis compared with published cases. Case Rep Dermatol Med 2016; 2016: 5095781
27 Techasatian L, Waraasawapati S, Jetsrisuparb C, Jetsrisuparb A. Hematidrosis: a report with histological and biochemical documents. Int J Dermatol 2016; 55 (08) 916-918
28 Jayaraman AR, Kannan P, Jayanthini V. An interesting case report of hematohidrosis. Indian J Psychol Med 2017; 39 (01) 83-85
29 Yeşilova Y, Turan E, Aksoy M. Hematidrosis on the forehead following trauma: a case report. Int J Dermatol 2017; 56 (02) 212-214
30 Maglie R, Caproni M. A case of blood sweating: hematohidrosis syndrome. CMAJ 2017; 189 (42) E1314
31 Ricci F, Oranges T, Novembre E. et al. Haematohidrosis treated with propranolol: a case report. Arch Dis Child 2019; 104 (02) 171
32 Shahgholi E. A case series of hematohidrosis: a puzzling medical phenomenon. Turk J Pediatr 2018; 60 (06) 757-761
33 Pari T. Hematohidrosis - a rare case. Indian Dermatol Online J 2019; 10 (03) 334-335
34 Hansson K, Johansson EK, Albåge M, Ballardini N. Paediatric haematohidrosis: an overview of a rare but clinically distinct condition. Acta Paediatr 2019; 108 (06) 1023-1027
35 Meyer J, Spacil K, Stehr M, Hinrichs W, Haller S, Schäfer FM. Hematidrosis after head injury - a case report. Klin Padiatr 2019; 231 (06) 326-327
36 Das D, Kumari P, Poddar A, Laha T. Bleeding to life: a case series of hematohidrosis and hemolacria. Indian J Pediatr 2020; 87 (01) 84
37 Murota H, Kotobuki Y, Yamaga K, Yoshioka Y. Female child with hematidrosis of the palm: case report and published work review. J Dermatol 2020; 47 (02) 166-168
38 Matsuoka R, Tanaka M. Hematidrosis in a Japanese girl: treatment with propranolol and psychotherapy. Pediatr Int 2020; 62 (08) 1001-1002
39 Corrà A, Quintarelli L, Caproni M. Bleeding from the oral cavity: a new case of hematohidrosis. Int J Dermatol 2020; 59 (11) e421-e422
40 Récher C. Hematidrosis as a manifestation of COVID-19 containment-induced stress. eJHaem 2020; 2 (01) 25
41 Salas-Alanis JC, Salas-Garza M, Goldust MM, Fajardo-Ramirez OR. Haematidrosis and haemolacria in a young adult. Clin Exp Dermatol 2021; 46 (02) 394-396
42 Hoover A, Fustino N, Sparks AO, Rokes C. Sweating blood: a case series of 2 siblings with hematohidrosis. J Pediatr Hematol Oncol 2021; 43 (02) 70-72
43 Tirthani K, Sardana K, Mathachan SR. Hematohidrosis of the mid-face and hands treated with oral oxybutynin. Pediatr Dermatol 2021; 38 (04) 962-963
44 Shafique DA, Hickman AW, Thorne A, Elwood HR, Zlotoff BJ. Pediatric hematidrosis - a case report and review of the literature and pathogenesis. Pediatr Dermatol 2021; 38 (05) 994-1003
45 Talwar M, Chidambaram AC, Mekala S, Parameswaran N, Delhikumar CG. Haematohidrosis in a 12-year-old boy: blood, sweat and tears. Paediatr Int Child Health 2021; 41 (04) 300-302
46 Alasfoor S, Albashari M, Alsermani A, Bakir M, Alsermani M, Almustanyir S. A strange occurrence of hematohidrosis: a case report from Saudi Arabia. Cureus 2022; 14 (01) e21682
47 Zheng J, Bian MR, Wu XQ. et al. Hematidrosis: a case report. Dermatol Ther 2022; 35 (06) e15462
48 Biswas D, Mondal DK, Biswas R, Halder A. Hematidrosis: a rare entity - case series and review of literature. Indian J Psychiatry 2022; 64 (04) 423-425
49 Mitra S, Chatterjee SS, Roy S, Kumar M. Stress-induced haematohidrosis: a case report. East Asian Arch Psychiatry 2022; 32 (03) 62-63
50 Ogbuneke JU, Allen JC. Case report and review of the pathophysiology and therapeutics of adult hematohidrosis. Cureus 2023; 15 (03) e36187