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CC BY-NC-ND 4.0 · International Journal of Practical Otolaryngology 2023; 06(01): e7-e15
DOI: 10.1055/s-0043-1770368
Original Article

Effects of Head and Neck Cancer Treatments on Gonadal Function in Adolescent and Young Adult Patients

Haruna Makita
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
2   Department of Otolaryngology, Tonami General Hospital, Tonami-shi, Toyama, Japan
,
Eiji Kobayashi
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Nobuyuki Hirai
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Takeshi Komori
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Takayoshi Ueno
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Yosuke Nakanishi
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Kazuhira Endo
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Satoru Kondo
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
,
Tomokazu Yoshizaki
1   Department of Otolaryngology—Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan
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Abstract

Otorhinolaryngologists often encounter and treat adolescents and young adults (AYA; aged 15–39 years) with cancer. Thus, it is important for them to recognize the impact of cancer treatment on the fertility of patients from this generation. In this retrospective review, we evaluated 60 AYA patients who were diagnosed with head and neck cancer at our department. Regarding the risk of gonadal toxicity due to cancer treatment, according to the classification by The Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients, one and three patients were found to be at high and intermediate risks, respectively. However, the risk of gonadal toxicity was not adequately explained in the guidelines; hence, they need to be revised. To preserve the fertility of AYA patients with head and neck cancer, patient information should be shared with appropriate obstetrics and gynecology or urology specialists before treatment. Furthermore, it is important to build a reproductive medicine network and ensure prompt collaboration with oncologists before initiating cancer treatment.

Keywords

AYA - head and neck cancer - oncofertility


Publication History

Received: 18 November 2022

Accepted: 03 March 2023

Article published online:
18 June 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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