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CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(04): 351-356
DOI: 10.1055/s-0043-1770925
Case Report and Review of Literature

Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma of the Brain in a Pediatric Patient: A Case Report and Review of Literature

Debanjan Sikdar
1   Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, India
,
Sweety Gupta
1   Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, India
,
Ravi Roshan
1   Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, India
,
Shruti Agarwal
2   Pathology, All India Institute of Medical Sciences, Rishikesh, India
,
Deepa M. Joseph 
1   Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, India
,
Manoj Gupta
1   Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, India
› Author Affiliations Source of Funding None.
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Abstract

Intracranial extraskeletal mesenchymal chondrosarcoma, which is characterized by undifferentiated mesenchymal cells in the presence of occasional pockets of mature hyaline cartilage, is rare in our clinical practice and commonly seen in young adults. In the pediatric population, only a few cases have been reported. In this article, we describe a case of primary recurrent intracranial mesenchymal chondrosarcoma in an 11-year-old boy well treated by surgery, radiation, and chemotherapy. We also reviewed all previously published reports on pediatric patients on the basis of their manifestations and management.

Keywords

reirradiation - intracranial - management - mesenchymal chondrosarcoma - outcome - pediatric

Authors' Contributions

D.S.: design, manuscript preparation; S.G.: clinical studies, data analysis; R.R.: literature search; S.A.: diagnosis; D.M.J.: manuscript editing; M.G.: manuscript review. This manuscript has been read and approved by all the authors.




Publication History

Article published online:
14 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Dahlin DC, Henderson ED. Mesenchymal chondrosarcoma. Further observations on a new entity. Cancer 1962; 15: 410-417
    CrossrefPubMedGoogle Scholar
  • 2 Lightenstein L, Bernstein D. Unusual benign and malignant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas. Cancer 1959; 12: 1142-1157
    CrossrefPubMedGoogle Scholar
  • 3 Lin L, Varikatt W, Dexter M, Ng T. Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system. Neuropathology 2012; 32 (01) 82-90
    CrossrefPubMedGoogle Scholar
  • 4 Harsh IV GRI, Wilson CB. Central nervous system mesenchymal chondrosarcoma. Case report. J Neurosurg 1984; 61 (02) 375-381
    CrossrefPubMedGoogle Scholar
  • 5 Bingaman KD, Alleyne Jr CH, Olson JJ. Intracranial extraskeletal mesenchymal chondrosarcoma: case report. Neurosurgery 2000; 46 (01) 207-211 , discussion 211–212
    CrossrefPubMedGoogle Scholar
  • 6 Hassounah M, Al-Mefty O, Akhtar M, Jinkins JR, Fox JL. Primary cranial and intracranial chondrosarcoma. A survey. Acta Neurochir (Wien) 1985; 78 (3–4): 123-132
    CrossrefPubMedGoogle Scholar
  • 7 Rollo JL, Green WR, Kahn LB. Primary meningeal mesenchymal chondrosarcoma. Arch Pathol Lab Med 1979; 103 (05) 239-243
    PubMedGoogle Scholar
  • 8 Waga S, Matsushima M, Ando K, Morii S. Intracranial chondrosarcoma with extracranial metastases. Case report. J Neurosurg 1972; 36 (06) 790-794
    CrossrefPubMedGoogle Scholar
  • 9 Scheithauer BW, Rubinstein LJ. Meningeal mesenchymal chondrosarcoma: report of 8 cases with review of the literature. Cancer 1978; 42 (06) 2744-2752
    CrossrefPubMedGoogle Scholar
  • 10 Heros RC, Martinez AJ, Ahn HS. Intracranial mesenchymal chondrosarcoma. Surg Neurol 1980; 14 (04) 311-317
    PubMedGoogle Scholar
  • 11 De Cecio R, Migliaccio I, Falleti J, Del Basso De Caro M, Pettinato G. Congenital intracranial mesenchymal chondrosarcoma: case report and review of the literature in pediatric patients. Pediatr Dev Pathol 2008; 11 (04) 309-313
    CrossrefPubMedGoogle Scholar
  • 12 González-Cámpora R, Otal Salaverri C, Gomez Pascual A, Hevia Vazquez A, Galera Davidson H. Mesenchymal chondrosarcoma of the retroperitoneum. Report of a case diagnosed by fine needle aspiration biopsy with immunohistochemical, electron microscopic demonstration of S-100 protein in undifferentiated cells. Acta Cytol 1995; 39 (06) 1237-1243
    PubMedGoogle Scholar
  • 13 Misra V, Singh PA. Cytodiagnosis of extraosseous mesenchymal chondrosarcoma of meninges: a case report. Acta Cytol 2008; 52 (03) 366-368
    CrossrefPubMedGoogle Scholar
  • 14 Trembath DG, Dash R, Major NM, Dodd LG. Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients. Cancer 2003; 99 (04) 211-216
    CrossrefPubMedGoogle Scholar
  • 15 Walaas L, Kindblom LG, Gunterberg B, Bergh P. Light and electron microscopic examination of fine-needle aspirates in the preoperative diagnosis of cartilaginous tumors. Diagn Cytopathol 1990; 6 (06) 396-408
    CrossrefPubMedGoogle Scholar
  • 16 Steiner GC, Mirra JM, Bullough PG. Mesenchymal chondrosarcoma. A study of the ultrastructure. Cancer 1973; 32 (04) 926-939
    CrossrefPubMedGoogle Scholar
  • 17 Flyger G, Freidenfeldt H, Orell SR. Intracerebral, possibly malignant osteochondrofibroma in a child. Acta Pathol Microbiol Scand 1963; 58: 299-305
    CrossrefPubMedGoogle Scholar
  • 18 Guccion JG, Font RL, Enzinger FM, Zimmerman LE. Extraskeletal mesenchymal chondrosarcoma. Arch Pathol 1973; 95 (05) 336-340
    PubMedGoogle Scholar
  • 19 Rushing EJ, Armonda RA, Ansari Q, Mena H. Mesenchymal chondrosarcoma: a clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system. Cancer 1996; 77 (09) 1884-1891
    CrossrefPubMedGoogle Scholar
  • 20 Kobayashi T, Yoshida J, Kageyama N, Makita Y, Aoyama I, Yamashita J. Mesenchymal chondrosarcoma arising from dura mater (author's transl) [in Japanese]. No Shinkei Geka 1980; 8 (09) 881-887
    PubMedGoogle Scholar
  • 21 Chhem RK, Bui BT, Calderon-Villar H, Fontaine S. Case report: primary mesenchymal chondrosarcoma of the brain. Clin Radiol 1992; 45 (06) 422-423
    CrossrefPubMedGoogle Scholar
  • 22 Schut L, Canady AI, Sutton LN, Bruce DA. Meningeal tumors in children. 1983. Pediatr Neurosurg 1994; 20 (03) 207-212 , discussion 213
    CrossrefPubMedGoogle Scholar
  • 23 Malik SN, Farmer PM, Hajdu SI, Rosenthal A. Mesenchymal chondrosarcoma of the cerebellum. Ann Clin Lab Sci 1996; 26 (06) 496-500
    PubMedGoogle Scholar
  • 24 Crosswell H, Buchino JJ, Sweetman R, Reisner A. Intracranial mesenchymal chondrosarcoma in an infant. Med Pediatr Oncol 2000; 34 (05) 370-374
    CrossrefPubMedGoogle Scholar
  • 25 Kan Z, Li H, Zhang J, You C. Intracranial mesenchymal chondrosarcoma: case report and literature review. Br J Neurosurg 2012; 26 (06) 912-914
    CrossrefPubMedGoogle Scholar
  • 26 Waliuddin A, Jamjoom AB, Thomas J. Intracranial extraskeletal mesenchymal chondrosarcoma. Neurosciences (Riyadh) 2006; 11 (03) 205-209
    Google Scholar
  • 27 Fanburg-Smith JC, Auerbach A, Marwaha JS. et al. Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. Ann Diagn Pathol 2010; 14 (01) 8-14
    CrossrefPubMedGoogle Scholar
  • 28 Kubota T, Hayashi M, Yamamoto S. Primary intracranial mesenchymal chondrosarcoma: case report with review of the literature. Neurosurgery 1982; 10 (01) 105-110
    CrossrefPubMedGoogle Scholar
  • 29 Parker JR, Zarabi MC, Parker Jr JC. Intracerebral mesenchymal chondrosarcoma. Ann Clin Lab Sci 1989; 19 (06) 401-407
    PubMedGoogle Scholar
  • 30 Salvador AH, Beabout JW, Dahlin DC. Mesenchymal chondrosarcoma–observations on 30 new cases. Cancer 1971; 28 (03) 605-615
    CrossrefPubMedGoogle Scholar
  • 31 Rodda RA, Franklin CI. Intracranial meningeal chondrosarcoma–probable mesenchymal type. Aust N Z J Surg 1984; 54 (04) 387-390
    CrossrefPubMedGoogle Scholar
  • 32 Sardi I, Massimino M, Genitori L, Buccoliero AM, Giangaspero F, Ferrari A. Intracranial mesenchymal chondrosarcoma: report of two pediatric cases. Pediatr Blood Cancer 2011; 56 (04) 685-686
    CrossrefPubMedGoogle Scholar
  • 33 Sadashiva N, Sharma A, Shukla D, Rajalakshmi P, Mahadevan A, Devi BI. Intracranial Extraskeletal Mesenchymal Chondrosarcoma. World Neurosurg 2016; 95 (618) e1-618.e6
    CrossrefPubMedGoogle Scholar