Download PDF
CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(01): 083-086
DOI: 10.1055/s-0043-1771046
Case Report with Review of Literature

Complete Remission of Cutaneous Metastasis from Invasive Breast Cancer with Abemaciclib plus Letrozole

Shaunak N. Valame 
1   Department of Medical Oncology, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, India
,
Dhruti D. Manek
2   Department of Pathology, CARE Pathology, Bhopal, Madhya Pradesh, India
› Author Affiliations Funding None.
› Further Information
Also available at
   Permissions and Reprints

Abstract

Skin metastases from internal malignancies can be the first clinical finding of cancer recurrence. If presentation is delayed, they may ulcerate and develop secondary infection. Through this case, we will highlight a case of breast cancer recurrence with extensive cutaneous metastases that clinically completely responded to oral systemic therapy, thereby obviating the need for chemotherapy and leading to stark improvement in performance status and quality of life.

Keywords

breast neoplasms - cyclin-dependent kinase inhibitor proteins - remission induction

Patient's Consent

Patient's consent was obtained to use her clinical images and PET scan images during publishing of this Case Report.


Contribution by Authors

Shaunak N. Valame was responsible for identifying the appropriate patient for treatment, counselling of patient, treatment protocols, starting of treatment and follow-ups, and providing the necessary data for compiling the article. Dhruti D. Manek contributed to reviewing the reports, literature search, and manuscript preparation and editing. The manuscript has been read and approved by both the authors.




Publication History

Article published online:
18 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995; 33 (2, Pt 1): 161-182 , quiz 183–186
    CrossrefPubMedGoogle Scholar
  • 2 Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 1993; 29 (2, Pt 1): 228-236
    CrossrefPubMedGoogle Scholar
  • 3 De Giorgi V, Grazzini M, Alfaioli B. et al. Cutaneous manifestations of breast carcinoma. Dermatol Ther 2010; 23 (06) 581-589
    CrossrefPubMedGoogle Scholar
  • 4 Hussein MR. Skin metastasis: a pathologist's perspective. J Cutan Pathol 2010; 37 (09) e1-e20
    CrossrefPubMedGoogle Scholar
  • 5 Pipkin CA, Lio PA. Cutaneous manifestations of internal malignancies: an overview. Dermatol Clin 2008; 26 (01) 1-15 , vii
    CrossrefPubMedGoogle Scholar
  • 6 Alcaraz I, Cerroni L, Rütten A, Kutzner H, Requena L. Cutaneous metastases from internal malignancies: a clinicopathologic and immunohistochemical review. Am J Dermatopathol 2012; 34 (04) 347-393
    CrossrefPubMedGoogle Scholar
  • 7 Cardoso F, Paluch-Shimon S, Senkus E. et al. 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5). Ann Oncol 2020; 31 (12) 1623-1649
    CrossrefPubMedGoogle Scholar
  • 8 Roncato R, Angelini J, Pani A. et al. CDK4/6 inhibitors in breast cancer treatment: potential interactions with drug, gene, and pathophysiological conditions. Int J Mol Sci 2020; 21 (17) 6350
    CrossrefPubMedGoogle Scholar
  • 9 Schoenlaub P, Sarraux A, Grosshans E, Heid E, Cribier B. Survival after cutaneous metastasis: a study of 200 cases. Ann Dermatol Venereol 2001; 128 (12) 1310-1315
    PubMedGoogle Scholar
  • 10 Johnston S, Martin M, Di Leo A. et al. MONARCH 3 final PFS: a randomized study of abemaciclib as initial therapy for advanced breast cancer. NPJ Breast Cancer 2019; 5: 5
    CrossrefPubMedGoogle Scholar