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CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(04): 357-362
DOI: 10.1055/s-0043-1771180
Case Report and Review of Literature

A Case Series of Gestational Choriocarcinoma with Review of Literature

Anusha Tanneru
1   Department of OBG, KS Hegde Medical Academy, NITTE University (to be deemed), Mangaluru, Dakshina Kannada, Karnataka, India
,
Vijith Shetty
2   Department of Medical Oncology, KS Hegde Medical Academy, NITTE University (to be deemed), Mangaluru, Dakshina Kannada, Karnataka, India
,
Neetha Nandan 
1   Department of OBG, KS Hegde Medical Academy, NITTE University (to be deemed), Mangaluru, Dakshina Kannada, Karnataka, India
› Author Affiliations Funding None declared.
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Abstract

Choriocarcinoma can be gestational and nongestational. Gestational choriocarcinoma is rare with an incidence of 9.2 in 40,000 pregnancies in Asian population. They can occur following molar, partial molar pregnancy, abortion, or delivery. It is detected by elevated levels of serum beta-human chorionic gonadotropin (beta-hCG) and by imaging modality. The need for histopathological diagnosis for choriocarcinoma is debatable. Six cases of choriocarcinoma are described with variable presentations and outcomes. Out of six cases, three were following vaginal delivery, two were after abortion, and one case was perimenopausal with antecedent pregnancy 10 years ago, unclear whether it was the cause for choriocarcinoma. Brain and lung metastasis were seen in three cases each; one case, which had metastasis to all organs, had worse prognosis and succumbed to the disease. All belonged to high-risk group according to International Federation of Gynaecology and Obstetrics score (8–13). The prognosis is usually very good, provided that prompt diagnosis and treatment are initiated early. Long-term follow-up with beta-hCG levels needs to be done to detect recurrence but it did not act like a prognostic indicator in our case series.

Keywords

choriocarcinoma - gestational trophoblastic neoplasia - metastasis

Authors' Contributions

All authors have agreed for the manuscript description. AT contributed to data collection and manuscript preparation. VS contributed to concept design and clinical treatment. NN contributed to manuscript preparation and editing.


Patient's Consent

Informed consent was obtained from all individual participants included in the study.




Publication History

Article published online:
22 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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