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CC BY 4.0 · Indian Journal of Neurosurgery 2023; 12(02): 168-173
DOI: 10.1055/s-0043-1771213
Original Article

Polymorphism of XRCC7 Gene and Risk of Glioma: A Prospective Case–Control Study

Deepak Choudhary
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Bhawna Mahajan 
2   Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research , New Delhi, India
,
Mamta Sumi
2   Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research , New Delhi, India
,
Binita Dholakia
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Sumit Bhandari
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Niraj Ghimire
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Sundeep Saluja
3   Department of GI Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Shaam Bodeliwala
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Wajid Nazir Wani 
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
,
Anita Jagetia
1   Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India
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Abstract

Objective The aim of this study is to determine association between polymorphism of XRCC7 gene and glioma.

Materials and Methods A case–control study was designed to analyze the prevalence of the various XRCC7 genotypes in 30 cases of histologically proven glioma and 30 age- and sex matched controls.

Result There is significantly higher prevalence of the GT and the TT genotypes of XRCC7 gene in cases of glioma as compared with control. The prevalence was significantly pronounced in two subgroups–middle aged and male gender. The presence of the XRCC7 GT or TT genotype conferred a significantly higher risk of developing glioma (odds ratio: 13.021,2.114–80.213).

Conclusion The presence of the T allele in XRCC7 polymorphism may increase the susceptibility to glioma.

Keywords

glioma - XRCC7 polymorphism


Publication History

Article published online:
11 August 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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