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CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci
DOI: 10.1055/s-0043-1772578
Brief Report

Diminished LC3 Expression with Unchanged Beclin 1 Levels in Right Atrial Appendage Tissue of Diabetic Patients Undergoing Coronary Artery Bypass Graft

Raji Sasikala Rajendran
1   Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
,
Nandini Ravikumar Jayakumari
1   Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
,
Vivek Velayudhan Pillai 
2   Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
,
Jayakumar Karunakaran
2   Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
,
Srinivas Gopala 
1   Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
› Author Affiliations Funding This study was supported by the Science & Engineering Research Board (SERB), Government of India (grant number: SB/SO/HS-051/2013), granted to Srinivas Gopala; Fellowship from INSPIRE, Department of Science and Technology (IF110342), Government of India, granted to Raji Sasikala Rajendran; and Fellowship from the Council of Scientific and Industrial Research (CSIR; 09/523(0076)/2011-EMR I), Government of India, granted to Nandini Ravikumar Jayakumari.
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Abstract

Type 2 diabetes potentiates the risk of heart failure. A vital physiologic process, autophagy, may be impaired in the diabetic heart. The aim of this study was to explore the autophagic status in a human diabetic heart. Techniques like immunohistochemistry and western blotting were employed to examine the expression of some of the important proteins involved in the autophagic machinery. Our brief study reports for the first time evidence of decreased cardiac autophagic levels in diabetic patients.

Keywords

autophagy - heart - type 2 diabetes


Publication History

Article published online:
18 December 2023

© 2023. National Academy of Medical Sciences (India). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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