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CC BY-NC-ND 4.0 · South Asian J Cancer 2025; 14(04): 711-715
DOI: 10.1055/s-0043-1772775
Original Article
Bone & Soft Tissue Section

Retrospective Outcome Analysis of Allogenic Bone Graft

Authors

  • Vikas Maheshwari 

    1   Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

  • Mohit Dhingra 

    1   Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

  • Divyansh Sharma

    1   Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

  • Aditya K. S. Gowda 

    1   Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

  • Arun Kurmi

    1   Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

  • Surabhi Das

    1   Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

Funding The author(s) received no financial support for the research, authorship, and/or publication of this article.
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Abstract

Bone bank has become an essential requirement for centers that perform tumor and reconstructive surgeries. It provides allogenic bone procured from cadavers as well as live donors in the form of surgical residues. Thus, we conducted a retrospective observational study on recipients who underwent various reconstructive procedures using fresh frozen allograft obtsined from the live donors through surgical residues in a newly established bone bank. The outcomes of cases operated where allogenic bone grafts were used between January 2018 and November 2020 were analyzed in terms of infection and time taken for the grafts to incorporate, allowing weight-bearing in the lower limbs. A total of 223 grafts were obtained as surgical residues from replacement surgeries and traumatic amputations performed on non-salvageable limbs. Out of these, 70 grafts were transplanted into eligible recipients, who were followed up for at least one year. Among the 70 recipients, 15 were lost to follow-up. The outcome data of the remaining 55 recipients was tabulated, including infections (early, delayed and late) and the achievement of weight-bearing milestones when transplanted in lower limbs. Out of the 55 cases, allografts were used alone in 20 cases, while in 35 cases, they were augmented by implants or cement. Two cases (3.6%) experienced acute infections, and another two cases (3.6%) had chronic infection. The mean time for weight-bearing was found to be 7 months when used alone and 3.5 months when augmented with cement or an implant. Additionally, five patients did not show complete integration of the graft. The results of using allogenic bone graft are quite encouraging, suggesting their potential as biological adjuvants in reconstructive surgeries.

Keywords

allograft - bone bank - outcome analysis - infection - graft incorporation

Availability of Data and Materials

All included studies used in this retrospective study are available online. The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Data regarding this study is not available in any electronic databases.


Ethical Approval Statement

Approval from the institutional ethics committee was obtained. (Letter No- AIIMS/IEC/22/02).


Consent to Publish

All authors have read the final prepared draft of the manuscript and approved this version, in its current format if considered further for publication.


Authors' Contribution

V.M. helped in planning of report, literature search, and writing of the manuscript. M.D. contributed to literature search, manuscript preparation, and correspondence. D.S. was involved in quality assessment of the included studies, writing, and revising of the manuscript. A.G. and S.D. wrote and revised the manuscript. A.K. helped in data management, outcome assessment, and revision of the manuscript.




Publication History

Article published online:
27 September 2023

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