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Synthesis 2024; 56(23): 3621-3629
DOI: 10.1055/s-0043-1773493
DOI: 10.1055/s-0043-1773493
paper
Efficient Synthesis of Benzospirocyclohexadienones via PIFA-Promoted Intramolecular Dearomative Spiroannulation
This work was financially supported by the National Natural Science Foundation of China (21772229).
Abstract
A rapid and convenient method for the synthesis of differently substituted spiro[cyclohexane-1,1′-isochromane]-2,5-dien-4-one derivatives via phenyliodine(III) bis(trifluoroacetate) (PIFA)-promoted intramolecular oxidative dearomatization at the para position is disclosed, with the aim of building a library of new spirocyclohexadienone scaffolds. Subsequently, this strategy is modified to access novel cyclohexanedienone-containing polycyclic compounds.
Key words
spirocyclic compounds - cyclohexadienones - hypervalent iodine(III) reagents - phenyliodine(III) bis(trifluoroacetate) - dearomatizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1773493.
- Supporting Information
Publication History
Received: 09 August 2024
Accepted after revision: 07 October 2024
Article published online:
22 October 2024
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