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Synthesis 2025; 57(03): 684-694
DOI: 10.1055/s-0043-1773494
DOI: 10.1055/s-0043-1773494
paper
N-Alkyl Isofagomine Lactams: Synthesis, Glycosidase Inhibition, and Antimicrobial Assessments
A.P. is supported by a European Union Horizon Europe MSCA DN-ID grant (101073263). K.K. is supported by the Spanish Ministry of Research and Innovation (RYC2021-033035-I). M.M., K.B.J., M.O.S, and E.L. are supported by the Universitetet i Stavanger (University of Stavanger). Ó.L. thanks Grant PID2020-116460RB-I00 funded by MCIN/AEI/10.13039/501100011033 for financial support.
Abstract
A series of six N-alkyl isofagomine lactam derivatives is synthesized over ten steps from d-arabinose. The compounds are evaluated as glycosidase inhibitors. It was found that the N-alkyl groups have a detrimental effect on the glycosidase inhibition activities, as the prepared N-alkyl isofagomine lactam derivatives are much less potent glycosidase inhibitors than native isofagomine lactam.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1773494.
- Supporting Information
Publication History
Received: 16 July 2024
Accepted after revision: 07 October 2024
Article published online:
22 October 2024
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