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Synthesis 2025; 57(04): 835-845
DOI: 10.1055/s-0043-1773500
DOI: 10.1055/s-0043-1773500
paper
A Portal to Highly Valuable Pyridonyl Vinyl Sulfonyl Fluorides and Aliphatic Sulfonyl Fluorides
We are grateful to the National Natural Science Foundation of China (Grant No. 22071190), Wuhan University of Technology, and Natural Science Foundation of Hubei Province (No. 2023AFA014) for financial support. We also extend our appreciation to Taif University, Saudi Arabia, for supporting this work through project number TU-DSPP-2024-85.
Abstract
A novel and efficient method for selective Michael addition of 2-pyridones to ethenesulfonyl fluoride (ESF) and 1-bromoethene-1-sulfonyl fluoride (BESF) has been developed for constructing a class of pyridonyl aliphatic sulfonyl fluorides and pyridonyl vinyl sulfonyl fluorides in good to excellent yields. This practical method features easy operation, wide substrate scope, and mild reaction conditions.
Key words
2-pyridones - pyridonyl vinyl sulfonyl fluorides - Michael addition - pyridonyl aliphatic sulfonyl fluorides - click chemistrySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1773500.
- Supporting Information
Publication History
Received: 04 September 2024
Accepted after revision: 29 October 2024
Article published online:
18 November 2024
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