Expected Usefulness of Fourth Dose of COVID-19 Vaccine for Patients with Underlying Solid Tumor who Previously Received the Primary Heterologous COVID-19 Vaccine

Sora Yasri; Viroj Wiwanitkit

doi:10.1055/s-0043-1774328

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(04): 301-305
DOI: 10.1055/s-0043-1774328

Original Article

Expected Usefulness of Fourth Dose of COVID-19 Vaccine for Patients with Underlying Solid Tumor who Previously Received the Primary Heterologous COVID-19 Vaccine

Sora Yasri

¹KM Center, Bangkok Thailand

,

Viroj Wiwanitkit

²Department of Biological Science, Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria

³Department of Community Medicine, Dr. DY Patil Medical College - Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India

› Author Affiliations

Abstract

Coronavirus disease 2019 (COVID-19) immunization frequently requires two standard doses. Due to the likelihood that the population may lose immunity after receiving a standard mass vaccination and the potential for the introduction of a new strain, several scientists are currently advocating the use of a booster dosage of the vaccine.

The authors of this retrospective study used a clinical model for immune response prediction to forecast how solid cancer patients will respond to the fourth dosage of the COVID-19 immunization. In the case of homologous primary backgrounds, the prospective rates of extension of protective efficacy for using viral vector and messenger ribonucleic acid (mRNA) COVID-19 vaccines for vaccinees with underlying solid tumor are equal to 11.5 and 16.5%, respectively. In the event of heterologous primary backgrounds, the prospective rates of extension of protective efficacy for using viral vector and mRNA COVID-19 vaccines are equal to 2.2 and 7.2%, respectively, for patients with underlying solid cancer. In conclusion, the fourth dose of the COVID-19 vaccine regimen had an effect on the immunogenicity of vaccine recipients with underlying malignancy.

Keywords

COVID-19 - dose - fourth - vaccine - cancer

Full Text

References

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