Subscribe to RSS
DOI: 10.1055/s-0043-1774331
Volar Locking Plate versus Closed Reduction and Immobilization for Distal Radius Fracture in the Elderly: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Funding None.Abstract
Introduction A systematic review and meta-analysis of randomized controlled trials was conducted to compare surgical treatment using open reduction and internal fixation (ORIF) with volar locking plates (VLP) to conservative treatment with closed reduction and immobilization in elderly patients aged ≥60 years with acute displaced distal radius fractures.
Methods A search of the MEDLINE, Scopus, and Central Register of Controlled Trials (CENTRAL) databases was conducted. Clinical and radiographic measures at 12 months were compared between groups by pooling the mean difference. The complication rates were compared by pooling relative risk ratios. Pooled mean differences of Disabilities of the Arm, Shoulder, and Hand (DASH) and Patient-Rated Wrist Evaluation (PRWE) results were compared with the published minimal clinically important difference (MCID) to evaluate the clinical relevance of the results.
Results The initial search yielded 766 records, from which 6 articles were selected for the final analysis. The results of the DASH questionnaire at 12 months of follow-up were significantly lower in the surgical treatment group with a mean difference (MD) of –3.61 points (95% confidence interval [CI]: –6.48 to –0.73). No statistically significant difference was found in the PRWE questionnaire (MD = –3.14 points [95% CI: –7.32 to 1.04]). Radiological results were significantly better in the surgical treatment group and no significant difference in the overall complication rate between the groups was detected. Found MD for DASH and PRWE did not reach the published MCIDs.
Conclusion This study suggests that for elderly patients aged ≥60 years with acute displaced distal radius fractures, surgical treatment using ORIF with VLP does not provide clinically relevant benefits compared with conservative treatment with closed reduction and immobilization at the 12-month follow-up, despite demonstrating better radiological results.
A Statement of the Location
This work was performed in the Federal State Budgetary Institution of the Ministry of Health of the Russian Federation National Medical Research Center of Traumatology and Orthopedics named after N.N. Priorov.
Publication History
Received: 05 June 2023
Accepted: 10 August 2023
Article published online:
07 November 2023
© 2023. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Nellans KW, Kowalski E, Chung KC. The epidemiology of distal radius fractures. Hand Clin 2012; 28 (02) 113-125
- 2 Jerrhag D, Englund M, Karlsson MK, Rosengren BE. Epidemiology and time trends of distal forearm fractures in adults: a study of 11.2 million person-years in Sweden. BMC Musculoskelet Disord 2017; 18 (01) 240
- 3 Stirling ERB, Johnson NA, Dias JJ. Epidemiology of distal radius fractures in a geographically defined adult population. J Hand Surg Eur Vol 2018; 43 (09) 974-982
- 4 Chung KC, Shauver MJ, Birkmeyer JD. Trends in the United States in the treatment of distal radial fractures in the elderly. J Bone Joint Surg Am 2009; 91 (08) 1868-1873
- 5 Rundgren J, Bojan A, Mellstrand Navarro C, Enocson A. Epidemiology, classification, treatment and mortality of distal radius fractures in adults: an observational study of 23,394 fractures from the national Swedish fracture register. BMC Musculoskelet Disord 2020; 21 (01) 88
- 6 Martinez-Mendez D, Lizaur-Utrilla A, de-Juan-Herrero J. Intra-articular distal radius fractures in elderly patients: a randomized prospective study of casting versus volar plating. J Hand Surg Eur Vol 2018; 43 (02) 142-147
- 7 Saving J, Severin Wahlgren S, Olsson K. et al. Nonoperative treatment compared with volar locking plate fixation for dorsally displaced distal radial fractures in the elderly: a randomized controlled trial. J Bone Joint Surg Am 2019; 101 (11) 961-969
- 8 Sirniö K, Leppilahti J, Ohtonen P, Flinkkilä T. Early palmar plate fixation of distal radius fractures may benefit patients aged 50 years or older: a randomized trial comparing 2 different treatment protocols. Acta Orthop 2019; 90 (02) 123-128
- 9 Arora R, Lutz M, Deml C, Krappinger D, Haug L, Gabl M. A prospective randomized trial comparing nonoperative treatment with volar locking plate fixation for displaced and unstable distal radial fractures in patients sixty-five years of age and older. J Bone Joint Surg Am 2011; 93 (23) 2146-2153
- 10 Bartl C, Stengel D, Bruckner T, Gebhard F. ORCHID Study Group. The treatment of displaced intra-articular distal radius fractures in elderly patients. Dtsch Arztebl Int 2014; 111 (46) 779-787
- 11 Hassellund SS, Williksen JH, Laane MM. et al. Cast immobilization is non-inferior to volar locking plates in relation to QuickDASH after one year in patients aged 65 years and older: a randomized controlled trial of displaced distal radius fractures. Bone Joint J 2021; 103-B (02) 247-255
- 12 Tahir M, Khan Zimri F, Ahmed N. et al. Plaster immobilization versus anterior plating for dorsally displaced distal radial fractures in elderly patients in Pakistan. J Hand Surg Eur Vol 2021; 46 (06) 647-653
- 13 Higgins JPT, Thomas J, Chandler J. et al , eds. Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (Updated February 2022). Cochrane; 2022. Accessed August 5, 2022 at: https://training.cochrane.org/handbook
- 14 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372 (71) n71
- 15 Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016; 5 (01) 210
- 16 Sterne JAC, Savović J, Page MJ. et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019; 366: l4898
- 17 R Core Team. R: A Language and Environment for Statistical Computing. Published online 2021. Accessed August 22, 2023 at: https://www.R-project.org/
- 18 Lawson A, Naylor JM, Buchbinder R. et al; Combined Randomised and Observational Study of Surgery for Fractures in the Distal Radius in the Elderly (CROSSFIRE) Study Group. Surgical plating vs closed reduction for fractures in the distal radius in older patients: a randomized clinical trial. JAMA Surg 2021; 156 (03) 229-237
- 19 Walenkamp MMJ, de Muinck Keizer RJ, Goslings JC, Vos LM, Rosenwasser MP, Schep NWL. The minimum clinically important difference of the patient-rated wrist evaluation score for patients with distal radius fractures. Clin Orthop Relat Res 2015; 473 (10) 3235-3241
- 20 Franchignoni F, Vercelli S, Giordano A, Sartorio F, Bravini E, Ferriero G. Minimal clinically important difference of the Disabilities of the Arm, Shoulder and Hand outcome measure (DASH) and its shortened version (QuickDASH). J Orthop Sports Phys Ther 2014; 44 (01) 30-39
- 21 Roy JS, MacDermid JC, Woodhouse LJ. Measuring shoulder function: a systematic review of four questionnaires. Arthritis Rheum 2009; 61 (05) 623-632
- 22 Schmitt JS, Di Fabio RP. Reliable change and minimum important difference (MID) proportions facilitated group responsiveness comparisons using individual threshold criteria. J Clin Epidemiol 2004; 57 (10) 1008-1018
- 23 Malay S, Chung KC. SUN Study Group. The minimal clinically important difference after simple decompression for ulnar neuropathy at the elbow. J Hand Surg Am 2013; 38 (04) 652-659
- 24 Stephens AR, Presson AP, McFarland MM. et al. Volar locked plating versus closed reduction and casting for acute, displaced distal radial fractures in the elderly: a systematic review and meta-analysis of randomized controlled trials. J Bone Joint Surg Am 2020; 102 (14) 1280-1288
- 25 Beaton DE, Wright JG, Katz JN. Upper Extremity Collaborative Group. Development of the QuickDASH: comparison of three item-reduction approaches. J Bone Joint Surg Am 2005; 87 (05) 1038-1046
- 26 Polson K, Reid D, McNair PJ, Larmer P. Responsiveness, minimal importance difference and minimal detectable change scores of the shortened disability arm shoulder hand (QuickDASH) questionnaire. Man Ther 2010; 15 (04) 404-407
- 27 Sorensen AA, Howard D, Tan WH, Ketchersid J, Calfee RP. Minimal clinically important differences of 3 patient-rated outcomes instruments. J Hand Surg Am 2013; 38 (04) 641-649
- 28 Gutiérrez-Espinoza H, Araya-Quintanilla F, Olguín-Huerta C. et al. Effectiveness of surgical versus conservative treatment of distal radius fractures in elderly patients: a systematic review and meta-analysis. Orthop Traumatol Surg Res 2022; 108 (05) 103323
- 29 Hooper RC, Zhou N, Wang L, Shauver MJ, Chung KC. WRIST Group. Pre-injury activity predicts outcomes following distal radius fractures in patients age 60 and older. PLoS One 2020; 15 (05) e0232684
- 30 Jayaram M, Wu H, Yoon AP, Kane RL, Wang L, Chung KC. Comparison of distal radius fracture outcomes in older adults stratified by chronologic vs physiologic age managed with casting vs surgery. JAMA Netw Open 2023; 6 (02) e2255786
- 31 Chung KC, Kim HM, Malay S, Shauver MJ. WRIST Group. Comparison of 24-month outcomes after treatment for distal radius fracture: the WRIST randomized clinical trial. JAMA Netw Open 2021; 4 (06) e2112710
- 32 Chung KC, Kim HM, Malay S, Shauver MJ. Wrist and Radius Injury Surgical Trial Group. The wrist and radius injury surgical trial: 12-month outcomes from a multicenter international randomized clinical trial. Plast Reconstr Surg 2020; 145 (06) 1054e-1066e
- 33 Chung KC, Cho HE, Kim Y, Kim HM, Shauver MJ. WRIST Group. Assessment of anatomic restoration of distal radius fractures among older adults: a secondary analysis of a randomized clinical trial. JAMA Netw Open 2020; 3 (01) e1919433
- 34 Lawson A, Naylor J, Buchbinder R. et al; Combined Randomised and Observational Study of Surgery for Fractures in the Distal Radius in the Elderly (CROSSFIRE) Study Group. Plating vs closed reduction for fractures in the distal radius in older patients: a secondary analysis of a randomized clinical trial. JAMA Surg 2022; 157 (07) 563-571
- 35 Yoon AP, Wang Y, Wang L, Chung KC. and the WRIST Group. What are the tradeoffs in outcomes after casting versus surgery for closed extraarticular distal radius fractures in older patients? A statistical learning model. Clin Orthop Relat Res 2021; 479 (12) 2691-2700
- 36 Sharma H, Khare GN, Singh S, Ramaswamy AG, Kumaraswamy V, Singh AK. Outcomes and complications of fractures of distal radius (AO type B and C): volar plating versus nonoperative treatment. J Orthop Sci 2014; 19 (04) 537-544
- 37 Dehghani M, Ravanbod H, Piri Ardakani M, Tabatabaei Nodushan MH, Dehghani S, Rahmani M. Surgical versus conservative management of distal radius fracture with coronal shift; a randomized controlled trial. Int J Burns Trauma 2022; 12 (02) 66-72
- 38 Südow H, Severin S, Wilcke M, Saving J, Sköldenberg O, Navarro CM. Non-operative treatment or volar locking plate fixation for dorsally displaced distal radius fractures in patients over 70 years: a three year follow-up of a randomized controlled trial. BMC Musculoskelet Disord 2022; 23 (01) 447
- 39 Deune EG. A prospective randomized study with no clinically important differences in closed vs open treatment for distal radius fracture in elderly individuals. JAMA Surg 2021; 156 (03) 237-238
- 40 Day CS, Maniwa K, Wu WK. More evidence that volar locked plating for distal radial fractures does not offer a functional advantage over traditional treatment options. J Bone Joint Surg Am 2013; 95 (19) e1471-e1472
- 41 Trevisan C, Klumpp R, Nava V, Riccardi D, Recalcati W. Surgical versus conservative treatment of distal radius fractures in elderly. Aging Clin Exp Res 2013; 25 (Suppl. 01) S83-S84
- 42 Wahlgren SS. Unstable Dorsally Displaced Fractures of the Distal Radius in the Elderly. A Randomized Comparison between Operative Fixation and Plaster Cast Treatment. clinicaltrials.gov; 2019. Accessed July 4, 2022 at: https://clinicaltrials.gov/ct2/show/NCT01268397
- 43 Chung DKC. A Clinical Trial for the Surgical Treatment of Elderly Distal Radius Fractures. The Wrist and Radius Injury Surgical Trial (WRIST). clinicaltrials.gov; 2019. Accessed July 4, 2022 at: https://clinicaltrials.gov/ct2/show/NCT01589692
- 44 Ärzteblatt DÄG Redaktion Deutsches. The Treatment of Displaced Intra-articular Distal Radius Fractures in Elderly Patients (14.11.2014). Deutsches Ärzteblatt. Published 2014. Accessed July 6, 2022 at: https://www.aerzteblatt.de/int/archive/article?id=163522
- 45 Ter Meulen DP, Mulders MAM, Kruiswijk AA. et al; DART Study Group. Effectiveness and cost-effectiveness of surgery versus casting for elderly patients with Displaced intra-Articular type C distal Radius fractures: protocol of a randomised controlled Trial with economic evaluation (the DART study). BMJ Open 2022; 12 (04) e051658
- 46 Bell K, Duckworth A. Comparing surgical fixation and conservative management using a cast in wrist fractures in people aged 65 years and older. https://trialsearch.who.int/Trial2.aspx?TrialID=ISRCTN95922938 Published online March 31, 2022. Accessed August 22, 2023