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DOI: 10.1055/s-0043-1775032
Oxidation of Eugenol Derivatives with KMnO4 and CrO3
We acknowledge the Fonds De La Recherche Scientifique (FNRS grant GEQ UG02222F) for financial support that was used to purchase the single-crystal X-ray diffractometer.
Abstract
This study aims to delineate the synthesis of eugenol derivatives, starting with hydroxyl group protection and then the subsequent oxidation stages. Initially, eugenol underwent conversion into acetyleugenol and benzyleugenol during the protection phase. Subsequently, a kinetic oxidation of acetyleugenol with KMnO4 via GC-MS analysis resulted in the identification of four compounds. The kinetic investigation indicated the primary formation of diolacetyleugenol, succeeded by aldehyde eugenol, which further gets converted into its respective carboxylic acid. Additionally, acetyleugenol and benzyleugenol underwent oxidation with CrO3, yielding the corresponding carboxylic acids.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/0043-1775032.
- Supporting Information
Publication History
Received: 18 May 2024
Accepted after revision: 17 July 2024
Article published online:
05 August 2024
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