Spiro-heterocycles have attracted significant interest due to their unique biological properties with fewer side effects compared to traditional drugs. Herein, a novel method is reported for the synthesis of a series of spiro-heterocycles possessing a quinoline motif. The strategy utilizes rhodanine derivatives, hydrazonoyl chlorides, and 2-chloroquinoline-3-carbaldehyde, and proceeds via a one-pot sequential pseudo-five-component reaction. The reactions are found to proceed in a regioselective and chemoselective manner.
Key words
rhodanine - hydrazonoyl chlorides - 2-chloroquinoline-3-carbaldehyde - 4,6-dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones - five-component reaction - regioselective - chemoselective - ultrasound