Synthesis, Table of Contents Synthesis 2024; 56(23): 3637-3645DOI: 10.1055/s-0043-1775404 paper Recyclable Pd(OAc)2/2P(3-tol)3/PEG-400 System for Regio- and Stereoselective Addition of Boronic Acids to Ynamides Li Wei , Rong Liu , Mingzhong Cai ∗ Recommend Article Abstract Buy Article All articles of this category Abstract Pd(OAc)2/2P(3-tol)3 in poly(ethylene glycol) (PEG-400) is shown to be a highly efficient catalyst for the regio- and stereoselective addition of boronic acids to ynamides. The reaction proceeds smoothly at 70 °C with Na2CO3 as base, delivering a variety of (Z)-α,β-disubstituted enamides in good to excellent yields with high regio- and stereoselectivity. The isolation of the crude products can be facilely performed by extraction with diethyl ether and more importantly, the Pd(OAc)2/2P(3-tol)3/PEG-400 system could be readily recycled and reused more than six times without any significant loss of its catalytic efficiency. 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