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Synthesis 2025; 57(09): 1640-1650
DOI: 10.1055/s-0043-1775446
paper

Design and Synthesis of a Novel 1,2,4-Oxadiazole Derivative: 3-(3-(5-((4-Phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl) phenoxy)propan-2-olamines

Deepak Kumar
a   Department of Applied Sciences, Chemistry, NIMS University, Jaipur, India
b   Jubilant Biosys Ltd., Greater Noida (UP) 201310, India
,
Ganesh Shinde
a   Department of Applied Sciences, Chemistry, NIMS University, Jaipur, India
b   Jubilant Biosys Ltd., Greater Noida (UP) 201310, India
,
Vivek Yadav
c   Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi, India
,
Suryakanta Dalai
b   Jubilant Biosys Ltd., Greater Noida (UP) 201310, India
,
Mukesh Jangir∗
a   Department of Applied Sciences, Chemistry, NIMS University, Jaipur, India
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Abstract

The synthesis of novel heterocyclic 3-(3-(5-((4-phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl)phenoxy)propan-2-olamine derivatives, in particular piperazine and piperidine derivatives of 1,2,4-oxadiazole, is reported. These compounds are a distinguished motif for biological studies. An effective piperazine and piperidine derivative methodology on 1,2,4-oxadiazole substrates has been developed. This pathway, along with good yields and clean reactions, has a broad substrate scope and provides new biologically useful moieties that can be further investigated for their applicability.

Key words

oxadiazoles - alkylation - synthesis - heterocycles - cyclization

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775446. Included are copies of 1H NMR and HRMS spectra of compounds 9.
  • Supporting Information


Publication History

Received: 24 November 2024

Accepted after revision: 19 January 2025

Article published online:
01 April 2025

© 2025. Thieme. All rights reserved

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