Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins

Abstract

This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on entire antigen.

Keywords

molecular mimicry - Trumenba vaccine - factor H-binding protein - human proteome - adverse events

Publikationsverlauf

Artikel online veröffentlicht:
16. November 2023

• References

• 1 Hollingshead S, Tang CM. An overview of Neisseria meningitidis . Methods Mol Biol 2019; 1969: 1-16
• 2 Biolchi A, Tomei S, Brunelli B. et al. 4CMenB immunization induces serum bactericidal antibodies against non-serogroup B meningococcal strains in adolescents. Infect Dis Ther 2021; 10 (01) 307-316
• 3 Seib KL, Scarselli M, Comanducci M, Toneatto D, Masignani V. Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen. Expert Rev Vaccines 2015; 14 (06) 841-859
• 4 FDA. Accessed October 30, 2023 at: https://www.fda.gov/media/89936/download
• 5 Kanduc D. Molecular mimicry between respiratory syncytial virus F antigen and the human proteome. Glob Med Genet 2023; 10 (01) 19-21
• 6 Kanduc D. Exposure to SARS-CoV-2 and infantile diseases. Glob Med Genet 2023; 10 (02) 72-78
• 7 Kanduc D. Homology, similarity, and identity in peptide epitope immunodefinition. J Pept Sci 2012; 18 (08) 487-494
• 8 Kanduc D. Pentapeptides as minimal functional units in cell biology and immunology. Curr Protein Pept Sci 2013; 14 (02) 111-120
• 9 Kanduc D. Hydrophobicity and the physico-chemical basis of immunotolerance. Pathobiology 2020; 87 (04) 268-276
• 10 Kanduc D. The role of proteomics in defining autoimmunity. Expert Rev Proteomics 2021; 18 (03) 177-184
• 11 UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res 2019; 47 (D1): D506-D515
• 12 Izumikawa T, Saigoh K, Shimizu J, Tsuji S, Kusunoki S, Kitagawa H. A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1. Biochim Biophys Acta 2013; 1830 (10) 4806-4812
• 13 Bronstein JM, Tiwari-Woodruff S, Buznikov AG, Stevens DB. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. J Neurosci Res 2000; 59 (06) 706-711
• 14 Wu L, Peng J, Ma Y. et al. Leukodystrophy associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFAF1 gene. Mitochondrial DNA A DNA Mapp Seq Anal 2016; 27 (02) 1034-1037
• 15 Vallat JM, Nizon M, Magee A. et al. Contactin-associated protein 1 (CNTNAP1) mutations induce characteristic lesions of the paranodal region. J Neuropathol Exp Neurol 2016; 75 (12) 1155-1159
• 16 Coutelier M, Goizet C, Durr A. et al. Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia. Brain 2015; 138 (Pt 8): 2191-2205
• 17 Bao X, Wu Y, Wong LJ. et al. Alpers syndrome with prominent white matter changes. Brain Dev 2008; 30 (04) 295-300
• 18 Synofzik M, Haack TB, Kopajtich R. et al. Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration. Am J Hum Genet 2014; 95 (06) 689-697
• 19 Edvardson S, Cinnamon Y, Jalas C. et al. Hereditary sensory autonomic neuropathy caused by a mutation in dystonin. Ann Neurol 2012; 71 (04) 569-572
• 20 Guernsey DL, Jiang H, Bedard K. et al. Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease. PLoS Genet 2010; 6 (08) e1001081
• 21 Stendel C, Roos A, Deconinck T. et al. Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, Frabin/FGD4. Am J Hum Genet 2007; 81 (01) 158-164
• 22 Meretoja J. Genetic aspects of familial amyloidosis with corneal lattice dystrophy and cranial neuropathy. Clin Genet 1973; 4 (03) 173-185
• 23 Soong BW, Huang YH, Tsai PC. et al. Exome sequencing identifies GNB4 mutations as a cause of dominant intermediate Charcot-Marie-Tooth disease. Am J Hum Genet 2013; 92 (03) 422-430
• 24 Patton BL. Laminins of the neuromuscular system. Microsc Res Tech 2000; 51 (03) 247-261
• 25 Tingaud-Sequeira A, Raldúa D, Lavie J. et al. Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiol Dis 2017; 98: 36-51
• 26 Ruskamo S, Nieminen T, Kristiansen CK. et al. Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2. Sci Rep 2017; 7 (01) 6510
• 27 Moldovan M, Alvarez S, Pinchenko V. et al. Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons. Brain 2011; 134 (Pt 2): 585-601
• 28 Rosenbaum T, Kim HA, Boissy YL, Ling B, Ratner N. Neurofibromin, the neurofibromatosis type 1 Ras-GAP, is required for appropriate P0 expression and myelination. Ann N Y Acad Sci 1999; 883: 203-214
• 29 McFerrin J, Patton BL, Sunderhaus ER, Kretzschmar D. NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers. Glia 2017; 65 (05) 804-816
• 30 Duarri A, Jezierska J, Fokkens M. et al. Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19. Ann Neurol 2012; 72 (06) 870-880
• 31 Raffaele Di Barletta M, Ricci E, Galluzzi G. et al. Different mutations in the LMNA gene cause autosomal dominant and autosomal recessive Emery-Dreifuss muscular dystrophy. Am J Hum Genet 2000; 66 (04) 1407-1412
• 32 Chen YZ, Hashemi SH, Anderson SK. et al. Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease. Neurobiol Dis 2006; 23 (01) 97-108
• 33 Huck JH, Verhoeven NM, Struys EA, Salomons GS, Jakobs C, van der Knaap MS. Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy. Am J Hum Genet 2004; 74 (04) 745-751
• 34 Varon R, Gooding R, Steglich C. et al. Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome. Nat Genet 2003; 35 (02) 185-189
• 35 Breckpot J, Takiyama Y, Thienpont B. et al. A novel genomic disorder: a deletion of the SACS gene leading to spastic ataxia of Charlevoix-Saguenay. Eur J Hum Genet 2008; 16 (09) 1050-1054
• 36 Dijkmans TF, van Hooijdonk LW, Fitzsimons CP, Vreugdenhil E. The doublecortin gene family and disorders of neuronal structure. Cent Nerv Syst Agents Med Chem 2010; 10 (01) 32-46
• 37 Boonsimma P, Michael Gasser M, Netbaramee W. et al. Mutational and phenotypic expansion of ATP1A3-related disorders: report of nine cases. Gene 2020; 749: 144709
• 38 Howard HC, Mount DB, Rochefort D. et al. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet 2002; 32 (03) 384-392
• 39 Abrams AJ, Hufnagel RB, Rebelo A. et al. Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nat Genet 2015; 47 (08) 926-932
• 40 Holzerova E, Danhauser K, Haack TB. et al. Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration. Brain 2016; 139 (Pt 2): 346-354
• 41 Nishino I, Spinazzola A, Hirano M. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science 1999; 283 (5402): 689-692
• 42 Ibdah JA, Tein I, Dionisi-Vici C. et al. Mild trifunctional protein deficiency is associated with progressive neuropathy and myopathy and suggests a novel genotype-phenotype correlation. J Clin Invest 1998; 102 (06) 1193-1199
• 43 Strom TM, Hörtnagel K, Hofmann S. et al. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Hum Mol Genet 1998; 7 (13) 2021-2028
• 44 Palmer EE, Kumar R, Gordon CT. et al; DDD Study. A recurrent de novo nonsense variant in ZSWIM6 results in severe intellectual disability without frontonasal or limb malformations. Am J Hum Genet 2017; 101 (06) 995-1005
• 45 Sheikh KA, Sun J, Liu Y. et al. Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A 1999; 96 (13) 7532-7537